INT14619

Context Info Confidence 0.62 First Reported 1983 Last Reported 2008 Negated 1 Speculated 0 Reported most in Abstract Documents 18 Total Number 18 Disease Relevance 7.73 Pain Relevance 3.94

hydrolase activity, acting on glycosyl bonds (NAGLU) lysosome (NAGLU)

Anatomy Link Frequency spinal 2 limb 2 urine 2 NAGLU (Homo sapiens)

Pain Link Frequency Relevance Heat Restless leg syndrome 60 99.92 cINOD 16 99.24 anesthesia 27 98.00 halothane 1 96.72 corticosteroid 6 94.80 rheumatoid arthritis 4 94.44 Inflammation 12 93.92 diclofenac 7 84.40 spinal inflammation 5 82.48 Arthritis 1 79.76

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 62 99.92 Disorders Of Creatine Metabolism 5 99.24 Uremia 3 97.60 Cv Unclassified Under Development 4 95.92 Proteinuria 11 95.84 Rheumatoid Arthritis 4 94.44 INFLAMMATION 27 93.92 Cyst 2 93.28 Pressure Volume 2 Under Development 4 93.20 Focal Segmental Glomerulosclerosis 1 92.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Creatinine clearance was slightly more affected by iodixanol, whereas the increase in renal excretion of N-acetyl-beta-glucosaminidase (NAG) in the first 24-h collection period after the examination was significantly higher (p < 0.01) with iopamidol.

Positive_regulation (increase) of Localization (excretion) of N-acetyl-beta-glucosaminidase associated with disorders of creatine metabolism

1) Confidence 0.62 Published 1996 Journal Eur Radiol Section Abstract Doc Link 8797943 Disease Relevance 0.10 Pain Relevance 0

In addition, the increased urinary excretion of beta2-microglobulin (beta2MG) and N-acetyl-beta-D-glucosaminidase (NAG) on admission was also improved during the treatment.

Positive_regulation (increased) of Localization (excretion) of N-acetyl-beta-D-glucosaminidase

2) Confidence 0.60 Published 2008 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 18274699 Disease Relevance 0.81 Pain Relevance 0.37

Neither auranofin nor myocrisin were found to further significantly increase beta 2M and NAG excretion.

Positive_regulation (increase) of Localization (excretion) of NAG

3) Confidence 0.48 Published 1983 Journal Clin. Rheumatol. Section Abstract Doc Link 6432404 Disease Relevance 0.70 Pain Relevance 0.52

Increased urinary N-acetyl-beta-glucosaminidase excretions were seen in the low-flow and high-flow sevoflurane groups, but not in the low-flow isoflurane group (P < 0.01).

Positive_regulation (Increased) of Localization (excretions) of N-acetyl-beta-glucosaminidase

4) Confidence 0.46 Published 1998 Journal Anesthesiology Section Body Doc Link 9710388 Disease Relevance 0.07 Pain Relevance 0

Creatinine clearance was slightly more affected by iodixanol, whereas the increase in renal excretion of N-acetyl-beta-glucosaminidase (NAG) in the first 24-h collection period after the examination was significantly higher (p < 0.01) with iopamidol.

Positive_regulation (increase) of Localization (excretion) of NAG associated with disorders of creatine metabolism

5) Confidence 0.44 Published 1996 Journal Eur Radiol Section Abstract Doc Link 8797943 Disease Relevance 0.10 Pain Relevance 0

In addition, the increased urinary excretion of beta2-microglobulin (beta2MG) and N-acetyl-beta-D-glucosaminidase (NAG) on admission was also improved during the treatment.

Positive_regulation (increased) of Localization (excretion) of NAG

6) Confidence 0.43 Published 2008 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 18274699 Disease Relevance 0.81 Pain Relevance 0.37

The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was elevated in four patients; two had other biochemical evidence of renal damage while the other two patients appeared normal, although they had both received spinal irradiation in the past.

Positive_regulation (elevated) of Localization (excretion) of NAG in spinal

7) Confidence 0.41 Published 1987 Journal Br. J. Rheumatol. Section Abstract Doc Link 3664158 Disease Relevance 0.95 Pain Relevance 0.54

The urinary excretion of NAG increased after both spark gap lithotripsy using the modified HM3 and piezoelectric lithotripsy.

Positive_regulation (increased) of Localization (excretion) of NAG

8) Confidence 0.40 Published 1990 Journal Urol. Res. Section Abstract Doc Link 1699345 Disease Relevance 0.08 Pain Relevance 0.16

Short term therapies by NSAIDs were without influence on enzymuria but long term therapies produced a moderate increase of NAG excretion.

Positive_regulation (increase) of Localization (excretion) of NAG associated with cinod

9) Confidence 0.36 Published 1989 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 2571317 Disease Relevance 0.16 Pain Relevance 0.26

The increase in urinary NAG excretion was dose related with sevoflurane, but there was no difference in results of routine laboratory renal tests on days 2 and 3 after anesthesia among the three groups.

Positive_regulation (increase) of Localization (excretion) of NAG

10) Confidence 0.32 Published 1995 Journal Anesthesiology Section Body Doc Link 7661345 Disease Relevance 0 Pain Relevance 0

CONCLUSIONS: The authors concluded that sevoflurane anesthesia results in increased serum fluoride concentration, a tendency toward decreased maximal ability to concentrate urine, and increased excretion of NAG.

Positive_regulation (increased) of Localization (excretion) of NAG in urine

11) Confidence 0.32 Published 1995 Journal Anesthesiology Section Body Doc Link 7661345 Disease Relevance 0 Pain Relevance 0

However, the increase in urinary NAG excretion was not indicative of clinically significant renal damage in these patients with no preexisting renal disease.

Positive_regulation (increase) of Localization (excretion) of NAG

12) Confidence 0.32 Published 1995 Journal Anesthesiology Section Body Doc Link 7661345 Disease Relevance 0 Pain Relevance 0

Increases in urinary NAG excretion have been demonstrated in patients undergoing aortic surgery [35] and in patients with critical limb ischaemia [36] but has not previously been documented in patients with IC.

Positive_regulation (Increases) of Localization (excretion) of NAG in limb associated with restless leg syndrome and cv unclassified under development

13) Confidence 0.27 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.97 Pain Relevance 0.86

Significant increases in excretion of NAG and gamma-GTP were observed in TNG group.

Positive_regulation (increases) of Localization (excretion) of NAG

14) Confidence 0.20 Published 1989 Journal Masui Section Abstract Doc Link 2573742 Disease Relevance 0.24 Pain Relevance 0.15

Glucose, protein, albumin, and NAG excretion were not significantly increased after anesthesia.

Neg (not) Positive_regulation (increased) of Localization (excretion) of NAG

15) Confidence 0.20 Published 1998 Journal Anesthesiology Section Body Doc Link 9523801 Disease Relevance 0 Pain Relevance 0

The use of two types of potentially nephrotoxic drugs, like NSAID and gentamicin or NSAID with cyclosporin induced significant augmentation of NAG excretion.

Positive_regulation (augmentation) of Localization (excretion) of NAG associated with cinod

16) Confidence 0.11 Published 1994 Journal Arch. Immunol. Ther. Exp. (Warsz.) Section Abstract Doc Link 7487376 Disease Relevance 0.52 Pain Relevance 0.49

Five patients (CHN2) with a S beta 2m > or = 5 mg/liter had a markedly increased excretion of all LMWP, albumin and NAG (CHN1 vs.

Positive_regulation (increased) of Localization (excretion) of NAG

17) Confidence 0.04 Published 1995 Journal Kidney Int. Section Abstract Doc Link 8544416 Disease Relevance 1.90 Pain Relevance 0.19

Gentamicin markedly increased NAG excretion but this effect was reduced by ASA, probably as a result of lysosomal stabilization.

Positive_regulation (increased) of Localization (excretion) of NAG

18) Confidence 0.03 Published 1985 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 4049389 Disease Relevance 0.31 Pain Relevance 0.03

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