INT14619

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 7.73
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (NAGLU) lysosome (NAGLU)
Anatomy Link Frequency
spinal 2
limb 2
urine 2
NAGLU (Homo sapiens)
Pain Link Frequency Relevance Heat
Restless leg syndrome 60 99.92 Very High Very High Very High
cINOD 16 99.24 Very High Very High Very High
anesthesia 27 98.00 Very High Very High Very High
halothane 1 96.72 Very High Very High Very High
corticosteroid 6 94.80 High High
rheumatoid arthritis 4 94.44 High High
Inflammation 12 93.92 High High
diclofenac 7 84.40 Quite High
spinal inflammation 5 82.48 Quite High
Arthritis 1 79.76 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 62 99.92 Very High Very High Very High
Disorders Of Creatine Metabolism 5 99.24 Very High Very High Very High
Uremia 3 97.60 Very High Very High Very High
Cv Unclassified Under Development 4 95.92 Very High Very High Very High
Proteinuria 11 95.84 Very High Very High Very High
Rheumatoid Arthritis 4 94.44 High High
INFLAMMATION 27 93.92 High High
Cyst 2 93.28 High High
Pressure Volume 2 Under Development 4 93.20 High High
Focal Segmental Glomerulosclerosis 1 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Creatinine clearance was slightly more affected by iodixanol, whereas the increase in renal excretion of N-acetyl-beta-glucosaminidase (NAG) in the first 24-h collection period after the examination was significantly higher (p < 0.01) with iopamidol.
Positive_regulation (increase) of Localization (excretion) of N-acetyl-beta-glucosaminidase associated with disorders of creatine metabolism
1) Confidence 0.62 Published 1996 Journal Eur Radiol Section Abstract Doc Link 8797943 Disease Relevance 0.10 Pain Relevance 0
In addition, the increased urinary excretion of beta2-microglobulin (beta2MG) and N-acetyl-beta-D-glucosaminidase (NAG) on admission was also improved during the treatment.
Positive_regulation (increased) of Localization (excretion) of N-acetyl-beta-D-glucosaminidase
2) Confidence 0.60 Published 2008 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 18274699 Disease Relevance 0.81 Pain Relevance 0.37
Neither auranofin nor myocrisin were found to further significantly increase beta 2M and NAG excretion.
Positive_regulation (increase) of Localization (excretion) of NAG
3) Confidence 0.48 Published 1983 Journal Clin. Rheumatol. Section Abstract Doc Link 6432404 Disease Relevance 0.70 Pain Relevance 0.52
Increased urinary N-acetyl-beta-glucosaminidase excretions were seen in the low-flow and high-flow sevoflurane groups, but not in the low-flow isoflurane group (P < 0.01).
Positive_regulation (Increased) of Localization (excretions) of N-acetyl-beta-glucosaminidase
4) Confidence 0.46 Published 1998 Journal Anesthesiology Section Body Doc Link 9710388 Disease Relevance 0.07 Pain Relevance 0
Creatinine clearance was slightly more affected by iodixanol, whereas the increase in renal excretion of N-acetyl-beta-glucosaminidase (NAG) in the first 24-h collection period after the examination was significantly higher (p < 0.01) with iopamidol.
Positive_regulation (increase) of Localization (excretion) of NAG associated with disorders of creatine metabolism
5) Confidence 0.44 Published 1996 Journal Eur Radiol Section Abstract Doc Link 8797943 Disease Relevance 0.10 Pain Relevance 0
In addition, the increased urinary excretion of beta2-microglobulin (beta2MG) and N-acetyl-beta-D-glucosaminidase (NAG) on admission was also improved during the treatment.
Positive_regulation (increased) of Localization (excretion) of NAG
6) Confidence 0.43 Published 2008 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 18274699 Disease Relevance 0.81 Pain Relevance 0.37
The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was elevated in four patients; two had other biochemical evidence of renal damage while the other two patients appeared normal, although they had both received spinal irradiation in the past.
Positive_regulation (elevated) of Localization (excretion) of NAG in spinal
7) Confidence 0.41 Published 1987 Journal Br. J. Rheumatol. Section Abstract Doc Link 3664158 Disease Relevance 0.95 Pain Relevance 0.54
The urinary excretion of NAG increased after both spark gap lithotripsy using the modified HM3 and piezoelectric lithotripsy.
Positive_regulation (increased) of Localization (excretion) of NAG
8) Confidence 0.40 Published 1990 Journal Urol. Res. Section Abstract Doc Link 1699345 Disease Relevance 0.08 Pain Relevance 0.16
Short term therapies by NSAIDs were without influence on enzymuria but long term therapies produced a moderate increase of NAG excretion.
Positive_regulation (increase) of Localization (excretion) of NAG associated with cinod
9) Confidence 0.36 Published 1989 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 2571317 Disease Relevance 0.16 Pain Relevance 0.26
The increase in urinary NAG excretion was dose related with sevoflurane, but there was no difference in results of routine laboratory renal tests on days 2 and 3 after anesthesia among the three groups.
Positive_regulation (increase) of Localization (excretion) of NAG
10) Confidence 0.32 Published 1995 Journal Anesthesiology Section Body Doc Link 7661345 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: The authors concluded that sevoflurane anesthesia results in increased serum fluoride concentration, a tendency toward decreased maximal ability to concentrate urine, and increased excretion of NAG.
Positive_regulation (increased) of Localization (excretion) of NAG in urine
11) Confidence 0.32 Published 1995 Journal Anesthesiology Section Body Doc Link 7661345 Disease Relevance 0 Pain Relevance 0
However, the increase in urinary NAG excretion was not indicative of clinically significant renal damage in these patients with no preexisting renal disease.


Positive_regulation (increase) of Localization (excretion) of NAG
12) Confidence 0.32 Published 1995 Journal Anesthesiology Section Body Doc Link 7661345 Disease Relevance 0 Pain Relevance 0
Increases in urinary NAG excretion have been demonstrated in patients undergoing aortic surgery [35] and in patients with critical limb ischaemia [36] but has not previously been documented in patients with IC.
Positive_regulation (Increases) of Localization (excretion) of NAG in limb associated with restless leg syndrome and cv unclassified under development
13) Confidence 0.27 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.97 Pain Relevance 0.86
Significant increases in excretion of NAG and gamma-GTP were observed in TNG group.
Positive_regulation (increases) of Localization (excretion) of NAG
14) Confidence 0.20 Published 1989 Journal Masui Section Abstract Doc Link 2573742 Disease Relevance 0.24 Pain Relevance 0.15
Glucose, protein, albumin, and NAG excretion were not significantly increased after anesthesia.
Neg (not) Positive_regulation (increased) of Localization (excretion) of NAG
15) Confidence 0.20 Published 1998 Journal Anesthesiology Section Body Doc Link 9523801 Disease Relevance 0 Pain Relevance 0
The use of two types of potentially nephrotoxic drugs, like NSAID and gentamicin or NSAID with cyclosporin induced significant augmentation of NAG excretion.
Positive_regulation (augmentation) of Localization (excretion) of NAG associated with cinod
16) Confidence 0.11 Published 1994 Journal Arch. Immunol. Ther. Exp. (Warsz.) Section Abstract Doc Link 7487376 Disease Relevance 0.52 Pain Relevance 0.49
Five patients (CHN2) with a S beta 2m > or = 5 mg/liter had a markedly increased excretion of all LMWP, albumin and NAG (CHN1 vs.
Positive_regulation (increased) of Localization (excretion) of NAG
17) Confidence 0.04 Published 1995 Journal Kidney Int. Section Abstract Doc Link 8544416 Disease Relevance 1.90 Pain Relevance 0.19
Gentamicin markedly increased NAG excretion but this effect was reduced by ASA, probably as a result of lysosomal stabilization.
Positive_regulation (increased) of Localization (excretion) of NAG
18) Confidence 0.03 Published 1985 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 4049389 Disease Relevance 0.31 Pain Relevance 0.03

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