INT146190

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.64
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
plasma 2
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 12 99.84 Very High Very High Very High
Spinal cord 6 95.36 Very High Very High Very High
Thermal hyperalgesia 6 87.64 High High
withdrawal 2 73.20 Quite High
Inflammation 7 62.76 Quite High
Hyperalgesia 2 61.16 Quite High
Pain 2 25.00 Low Low
agonist 8 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 58 90.36 High High
Hyperalgesia 8 87.64 High High
Nociception 8 77.84 Quite High
INFLAMMATION 7 62.76 Quite High
Nervous System Injury 2 62.08 Quite High
Clostridium Infection 2 11.64 Low Low
Asthma 8 5.00 Very Low Very Low Very Low
Fever 5 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This mevalonate-induced RhoA translocation was also blocked by intrathecal pretreatment with GGTI-2133, indicating that the RhoA translocation is triggered by RhoA geranylgeranylation.
Negative_regulation (blocked) of Localization (translocation) of RhoA associated with intrathecal
1) Confidence 0.42 Published 2008 Journal Pain Section Abstract Doc Link 17764839 Disease Relevance 0.70 Pain Relevance 0.74
Intrathecal injection of mevalonate also produced RhoA translocation from cytosol to plasma membrane.
Negative_regulation (produced) of Localization (translocation) of RhoA in plasma associated with intrathecal
2) Confidence 0.42 Published 2008 Journal Pain Section Abstract Doc Link 17764839 Disease Relevance 0.71 Pain Relevance 0.76
Determination of active form of RhoA in BSM
Negative_regulation (Determination) of Localization (form) of RhoA
3) Confidence 0.37 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
Earlier studies indicated that the effect of simvastatin on the localization of RhoA is due to a shortage of geranylgeranyl diphosphate (GGPP) and can be prevented by the addition of geranylgeraniol (GGOH) (Houten et al 2003b).
Negative_regulation (prevented) of Localization (localization) of RhoA
4) Confidence 0.31 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.23 Pain Relevance 0

General Comments

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