INT146192

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 8.15
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
spinal 2
ECs 2
nerve 2
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 5 97.64 Very High Very High Very High
chemokine 7 95.28 Very High Very High Very High
Dorsal horn 4 93.64 High High
substance P 26 92.20 High High
Neuropathic pain 8 90.52 High High
agonist 19 88.24 High High
cytokine 17 86.36 High High
Inflammation 64 85.96 High High
intrathecal 9 84.12 Quite High
c fibre 16 82.48 Quite High
Disease Link Frequency Relevance Heat
Adhesions 3 100.00 Very High Very High Very High
Nervous System Injury 18 99.98 Very High Very High Very High
Nociception 17 99.52 Very High Very High Very High
Mevalonate Kinase Deficiency 232 99.48 Very High Very High Very High
Death 16 99.16 Very High Very High Very High
Demyelinating Disease 5 97.64 Very High Very High Very High
Apoptosis 51 96.88 Very High Very High Very High
Necrosis 3 96.64 Very High Very High Very High
Cancer 5 96.28 Very High Very High Very High
Hyperglycemia 2 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the current study also demonstrated a marked increase in the expression and activation of RhoA protein in BSMs of the AHR mice (Fig. 4 and 5).
Positive_regulation (increase) of Positive_regulation (activation) of RhoA protein
1) Confidence 0.60 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.13 Pain Relevance 0
In summary, we showed that protein isoprenylation in MKD cells is more sensitive to inhibition by simvastatin than in control cells, resulting in an increased, ectopic activation of soluble RhoA and Rac1 in MKD cells.
Positive_regulation (resulting) of Positive_regulation (activation) of RhoA associated with mevalonate kinase deficiency
2) Confidence 0.51 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 1.15 Pain Relevance 0.08
Our present results suggest that mevalonate sensitizes the spinal nociceptive transmission, which is mediated by the activation of ROCK following the RhoA geranylgeranylation.
Positive_regulation (mediated) of Positive_regulation (activation) of RhoA in spinal associated with nociception
3) Confidence 0.49 Published 2008 Journal Pain Section Abstract Doc Link 17764839 Disease Relevance 0.46 Pain Relevance 0.47
It is thus likely that ACh stimulation activates the upregulated RhoA (Fig. 5), resulting in a greater phosphorylation of MLC (Fig. 6) and contraction of BSMs in AHR mice.
Positive_regulation (activates) of Positive_regulation (upregulated) of RhoA
4) Confidence 0.43 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.43 Pain Relevance 0.19
These observations are in a good contrast with the previous findings that the nerve injury-induced activation of LPA1 receptor and RhoA causes functional changes in myelinated A-fibers, such as demyelination and up-regulation of Ca2+ channel ?
Positive_regulation (induced) of Positive_regulation (activation) of RhoA in nerve associated with demyelination and nervous system injury
5) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1562366 Disease Relevance 1.18 Pain Relevance 0.98
In these model conditions, activated 12/15LO regulates monocyte attachment to ECs in part by increasing expression of adhesion molecule ICAM-1 on the surface of ECs via activation of RhoA and NF-?
Positive_regulation (increasing) of Positive_regulation (activation) of RhoA in ECs associated with adhesions
6) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.85 Pain Relevance 0.24
To determine whether the observed increase of active GTP-bound RhoA and Rac1 during the different culturing conditions was due to activation of soluble or membrane-bound RhoA and Rac1, we studied separately the effect of simvastatin.
Positive_regulation (due) of Positive_regulation (activation) of RhoA
7) Confidence 0.34 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.53 Pain Relevance 0
In summary, we showed that protein isoprenylation in MKD cells is more sensitive to inhibition by simvastatin than in control cells, resulting in an increased, ectopic activation of soluble RhoA and Rac1 in MKD cells.
Positive_regulation (increased) of Positive_regulation (activation) of RhoA associated with mevalonate kinase deficiency
8) Confidence 0.34 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 1.10 Pain Relevance 0.08
The increase in total cellular levels of active RhoA and Rac1 due to simvastatin appears primarily, if not solely, caused by activation of soluble RhoA and Rac1 and not membrane-bound RhoA and Rac1.
Neg (not) Positive_regulation (caused) of Positive_regulation (activation) of RhoA
9) Confidence 0.34 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.10 Pain Relevance 0
RhoA/ROCK pathway mediates statin-dependent enhancement of Smad activation
Positive_regulation (dependent) of Positive_regulation (enhancement) of RhoA
10) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.81 Pain Relevance 0
Activation of RTN4R initiates a cascade that leads to the activation of RhoA and, ultimately, the inhibition of axonal growth [5]–[7].
Positive_regulation (leads) of Positive_regulation (activation) of RhoA
11) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.39 Pain Relevance 0.14

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