INT146193

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.00
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
nerve 2
respiratory 2
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 9 99.84 Very High Very High Very High
Neuropathic pain 16 96.76 Very High Very High Very High
Pain 13 92.84 High High
Spinal cord 9 92.72 High High
Demyelination 7 91.80 High High
Thermal hyperalgesia 4 85.00 Quite High
c fibre 17 84.36 Quite High
substance P 26 71.36 Quite High
withdrawal 1 70.56 Quite High
antagonist 15 68.48 Quite High
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 1 99.48 Very High Very High Very High
Infection 7 98.36 Very High Very High Very High
Parainfluenza Virus Infection 2 98.12 Very High Very High Very High
Nervous System Injury 18 97.96 Very High Very High Very High
Neuropathic Pain 20 96.76 Very High Very High Very High
Pain 11 92.84 High High
Demyelinating Disease 9 91.80 High High
Hyperalgesia 5 85.00 Quite High
Nociception 19 77.84 Quite High
Clostridium Difficile Infection 1 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This mevalonate-induced RhoA translocation was also blocked by intrathecal pretreatment with GGTI-2133, indicating that the RhoA translocation is triggered by RhoA geranylgeranylation.
Negative_regulation (blocked) of Positive_regulation (mevalonate-induced) of RhoA associated with intrathecal
1) Confidence 0.42 Published 2008 Journal Pain Section Abstract Doc Link 17764839 Disease Relevance 0.71 Pain Relevance 0.74
Inhibition of the RhoA downstream pathway of LPA1 receptor activation has shown that this pathway is essential for both nerve injury- and LPA-induced neuropathic pain.
Negative_regulation (Inhibition) of Positive_regulation (activation) of RhoA in nerve associated with nervous system injury and neuropathic pain
2) Confidence 0.34 Published 2006 Journal Mol Pain Section Body Doc Link PMC1562366 Disease Relevance 1.39 Pain Relevance 1.06
Inhibition of RhoA activation elicited by respiratory syncytial virus infection is implicated in the antiviral mechanism of the macrolide antibiotics bafilomycin and clarithromycin (Asada et al., 2009).
Negative_regulation (Inhibition) of Positive_regulation (activation) of RhoA in respiratory associated with infection and respiratory syncytial virus
3) Confidence 0.07 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.91 Pain Relevance 0.03

General Comments

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