INT146196

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 4.68
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
plasma 1
smooth muscle 1
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 16 100.00 Very High Very High Very High
intrathecal 18 99.22 Very High Very High Very High
Spinal cord 9 95.00 High High
Thermal hyperalgesia 9 87.28 High High
withdrawal 3 72.84 Quite High
Inflammation 33 62.40 Quite High
Hyperalgesia 3 60.80 Quite High
Pain 3 25.00 Low Low
abdominal pain 7 5.00 Very Low Very Low Very Low
Arthritis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mevalonate Kinase Deficiency 406 98.22 Very High Very High Very High
Hyperalgesia 12 87.28 High High
Nociception 12 84.48 Quite High
INFLAMMATION 33 62.40 Quite High
Nervous System Injury 3 61.72 Quite High
Clostridium Infection 4 10.68 Low Low
Fever 35 5.00 Very Low Very Low Very Low
Syndrome 21 5.00 Very Low Very Low Very Low
Asthma 16 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This mevalonate-induced RhoA translocation was also blocked by intrathecal pretreatment with GGTI-2133, indicating that the RhoA translocation is triggered by RhoA geranylgeranylation.
Localization (translocation) of RhoA associated with intrathecal
1) Confidence 0.78 Published 2008 Journal Pain Section Abstract Doc Link 17764839 Disease Relevance 0.70 Pain Relevance 0.74
This mevalonate-induced RhoA translocation was also blocked by intrathecal pretreatment with GGTI-2133, indicating that the RhoA translocation is triggered by RhoA geranylgeranylation.
Localization (translocation) of RhoA associated with intrathecal
2) Confidence 0.78 Published 2008 Journal Pain Section Abstract Doc Link 17764839 Disease Relevance 0.69 Pain Relevance 0.70
Intrathecal injection of mevalonate also produced RhoA translocation from cytosol to plasma membrane.
Localization (translocation) of RhoA in plasma associated with intrathecal
3) Confidence 0.78 Published 2008 Journal Pain Section Abstract Doc Link 17764839 Disease Relevance 0.71 Pain Relevance 0.76
Recent studies suggest a participation of RhoA in the agonist-induced Ca2+ sensitization of smooth muscle contraction [10].
Localization (sensitization) of RhoA in smooth muscle associated with agonist
4) Confidence 0.65 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0.10
Determination of active form of RhoA in BSM
Localization (form) of RhoA
5) Confidence 0.65 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
Earlier studies indicated that the effect of simvastatin on the localization of RhoA is due to a shortage of geranylgeranyl diphosphate (GGPP) and can be prevented by the addition of geranylgeraniol (GGOH) (Houten et al 2003b).
Localization (localization) of RhoA
6) Confidence 0.59 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.22 Pain Relevance 0
Fig. 2Effect of geranylgeranyltransferase inhibitor (GGTI) on the localization and activation of RhoA (a–e) and Rac1 (f–j).
Localization (localization) of RhoA
7) Confidence 0.59 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.25 Pain Relevance 0
Fig. 1Effect of simvastatin on the localization and activation of RhoA (a–e) and Rac1 (f–j).
Localization (localization) of RhoA
8) Confidence 0.59 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.78 Pain Relevance 0
To confirm that the observed effect of simvastatin on RhoA and Rac1 activation was due to a shortage of GGPP, we studied the effect of GGTI, an inhibitor of geranylgeranyl transferase, on localization and activation of RhoA and Rac1 and found that GGTI had a similar effect as simvastatin.
Localization (localization) of RhoA
9) Confidence 0.55 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.29 Pain Relevance 0
Using the same approach, i.e., reducing the flux through the pathway by incubating control and MKD cells with simvastatin, an inhibitor of HMG-CoA reductase, we now studied the effect on localization and activation of RhoA and Rac1.
Localization (localization) of RhoA associated with mevalonate kinase deficiency
10) Confidence 0.55 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.65 Pain Relevance 0
Effect of simvastatin on RhoA and Rac1 localization and activation
Localization (localization) of RhoA
11) Confidence 0.52 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.22 Pain Relevance 0
The effect of GGTI on RhoA and Rac1 localization and activation
Localization (localization) of RhoA
12) Confidence 0.52 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.18 Pain Relevance 0

General Comments

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