INT146198

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 5.86
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rock1) cytoskeleton (Rock1) cytoskeleton organization (Rock1)
kinase activity (Rock1) cytoplasm (Rock1)
Anatomy Link Frequency
spinal 1
filament 1
nerve 1
fibroblasts 1
Rock1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 29 99.16 Very High Very High Very High
Hyperalgesia 2 96.72 Very High Very High Very High
Inflammation 52 95.12 Very High Very High Very High
Kinase C 83 87.76 High High
intrathecal 12 83.48 Quite High
Spinal cord 7 77.92 Quite High
withdrawal 2 69.20 Quite High
Thermal hyperalgesia 6 65.72 Quite High
Pain 18 25.00 Low Low
metalloproteinase 31 10.60 Low Low
Disease Link Frequency Relevance Heat
Nociception 10 99.20 Very High Very High Very High
Death 21 98.96 Very High Very High Very High
INFLAMMATION 70 98.44 Very High Very High Very High
Sarcoma 42 98.12 Very High Very High Very High
Stress 15 98.00 Very High Very High Very High
Targeted Disruption 51 96.96 Very High Very High Very High
Apoptosis 98 96.88 Very High Very High Very High
Hyperalgesia 8 96.72 Very High Very High Very High
Nervous System Injury 2 95.80 Very High Very High Very High
Exencephaly /

Neural Tube Defects

1 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
shedding, i.e., activation of ROCK1 blocks basal and stimulated shedding while ROCK1 inhibition apparently relieves a tonic negative influence exerted on shedding by ROCK1 activity.
Positive_regulation (activation) of ROCK1
1) Confidence 0.49 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0.04
In studies aimed at independent confirmation of the involvement of ROCK activation in sAPP?
Positive_regulation (activation) of ROCK
2) Confidence 0.49 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0
Activation of ROCK1 occurs when a Rho protein binds to the Rho-binding domain, causing a conformational change that opens the kinase domain for the phosphorylation of downstream effectors [23].
Positive_regulation (Activation) of ROCK1
3) Confidence 0.49 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0
Our present results suggest that mevalonate sensitizes the spinal nociceptive transmission, which is mediated by the activation of ROCK following the RhoA geranylgeranylation.
Positive_regulation (activation) of ROCK in spinal associated with nociception
4) Confidence 0.36 Published 2008 Journal Pain Section Abstract Doc Link 17764839 Disease Relevance 0.45 Pain Relevance 0.46
shedding, we treated SweAPP N2a cells with arachidonic acid, an activator of ROCK.
Positive_regulation (activator) of ROCK
5) Confidence 0.36 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0
Conversely, DN ROCK1 alone activated shedding of sAPP?.
Positive_regulation (activated) of ROCK1
6) Confidence 0.36 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0
These investigators discovered that activation of ROCK1 may account for how nonsteroidal anti-inflammatory drugs specify the scissile bond within the APP transmembrane domain that is cleaved by presenilin/?
Positive_regulation (activation) of ROCK1 associated with inflammation and cinod
7) Confidence 0.36 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0.15 Pain Relevance 0.17
Taken together, these results suggest the existence of a reciprocal relationship between isoprenoid-mediated Rho/ROCK signaling and sAPP?
Positive_regulation (mediated) of ROCK
8) Confidence 0.36 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0 Pain Relevance 0.04
More specifically, the data indicate that ROCK1 activation blocks the effects of statins on APP ectodomain shedding, while ROCK1 blockade alone can mimic the effect of statins on APP shedding.
Positive_regulation (activation) of ROCK1
9) Confidence 0.33 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC543463 Disease Relevance 0.07 Pain Relevance 0
Activation of Rho/Rho kinase (ROCK) signaling has been reported to be involved in the initiation and maintenance of hyperalgesia caused by nerve injury and inflammation.
Positive_regulation (Activation) of ROCK in nerve associated with hyperalgesia, nervous system injury and inflammation
10) Confidence 0.24 Published 2008 Journal Pain Section Abstract Doc Link 17764839 Disease Relevance 0.51 Pain Relevance 0.39
These results indicate that tumorigenic cen3tel cells acquired a protease-independent type of invasion, which requires the activity of ROCK kinase.


Positive_regulation (requires) of ROCK kinase
11) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0 Pain Relevance 0
Rounded cell morphology and cortical actin rings depend on the activity of the Rho-effector kinase ROCK, which acts by increasing myosin-II-mediated actin filament stabilization and contraction [32].
Positive_regulation (depend) of ROCK in filament
12) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.24 Pain Relevance 0
In mouse 3T3 fibroblasts a switch to amoeboid movement was observed upon p53 inactivation [14], while up-regulation of the Rho/ROCK signalling was found in highly metastatic rat sarcoma cells, together with the loss of MMP2 activity and an increased generation of protrusive forces, typical of the amoeboid movement [21].
Positive_regulation (regulation) of ROCK in fibroblasts associated with sarcoma
13) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.67 Pain Relevance 0
RhoA/ROCK pathway mediates statin-dependent enhancement of Smad activation
Positive_regulation (enhancement) of ROCK
14) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.81 Pain Relevance 0
Rho-associated serine-threonine protein kinase (ROCK), one of the best characterized downstream effectors of Rho, is activated when it selectively binds to the active GTP-bound form of Rho.
Positive_regulation (activated) of ROCK
15) Confidence 0.05 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.81 Pain Relevance 0
Activated ROCK interacts with the actin cytoskeleton to promote stress-fiber formation and assembly of focal contacts (Kamai et al. 2003).
Positive_regulation (Activated) of ROCK associated with stress
16) Confidence 0.05 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.72 Pain Relevance 0
Rho-associated serine-threonine protein kinase (ROCK), one of the best characterized downstream effectors of Rho, is activated when it selectively binds to the active GTP-bound form of Rho.
Positive_regulation (activated) of Rho-associated
17) Confidence 0.05 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.82 Pain Relevance 0
This latter defect is due to a lack of LPA-mediated constitutive activation of the Rho-ROCK and LIM kinase pathways.
Positive_regulation (activation) of Rho-ROCK
18) Confidence 0.00 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.53 Pain Relevance 0

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