INT14624

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Context Info
Confidence 0.38
First Reported 1981
Last Reported 2010
Negated 8
Speculated 3
Reported most in Body
Documents 100
Total Number 105
Disease Relevance 33.22
Pain Relevance 69.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
neurons 11
nerve 5
spinal cord 3
nociceptors 3
T lymphocytes 3
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 7317 100.00 Very High Very High Very High
Neuropeptide 411 100.00 Very High Very High Very High
Nerve growth factor 357 100.00 Very High Very High Very High
Pain 356 100.00 Very High Very High Very High
projection neuron 312 100.00 Very High Very High Very High
Calcitonin gene-related peptide 225 100.00 Very High Very High Very High
Enkephalin 173 100.00 Very High Very High Very High
nav1.8 68 100.00 Very High Very High Very High
calcitonin gene related peptide 60 100.00 Very High Very High Very High
tetrodotoxin 33 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 358 100.00 Very High Very High Very High
Nociception 264 100.00 Very High Very High Very High
Targeted Disruption 403 99.88 Very High Very High Very High
Granuloma 294 99.58 Very High Very High Very High
Cystitis 37 99.56 Very High Very High Very High
Pruritus 182 99.48 Very High Very High Very High
Nervous System Injury 26 99.34 Very High Very High Very High
Hyperalgesia 97 99.16 Very High Very High Very High
Inflammatory Bowel Disease 117 98.96 Very High Very High Very High
Inflammatory Pain 18 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also used immunocytochemistry to analyze nerve injury-induced changes in substance P (SP) and NK-1 (SP) receptor expression in the spinal cord.
Gene_expression (expression) of SP in nerve associated with nervous system injury, spinal cord and substance p
1) Confidence 0.38 Published 1998 Journal Pain Section Abstract Doc Link 9696476 Disease Relevance 1.28 Pain Relevance 1.05
The characteristics of SP(1-7) binding sites are consistent with those expected for an SP N-terminal receptor.
Gene_expression (expected) of SP associated with substance p
2) Confidence 0.33 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1700082 Disease Relevance 0 Pain Relevance 0.62
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Neg (no) Gene_expression (expression) of Pax3 in TEK
3) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Gene_expression (expression) of Pax3 in TEK
4) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
A tritium-labeled aminoterminal heptapeptide of SP, 3H-SP(1-7), was synthesized, purified, and used to characterize the binding of a variety of fragments of SP and opioids in the mouse brain and spinal cord membranes.
Gene_expression (synthesized) of SP in spinal cord associated with opioid, spinal cord and substance p
5) Confidence 0.26 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1700082 Disease Relevance 0 Pain Relevance 0.84
A tritium-labeled aminoterminal heptapeptide of SP, 3H-SP(1-7), was synthesized, purified, and used to characterize the binding of a variety of fragments of SP and opioids in the mouse brain and spinal cord membranes.
Gene_expression (synthesized) of SP in spinal cord associated with opioid, spinal cord and substance p
6) Confidence 0.26 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1700082 Disease Relevance 0 Pain Relevance 0.84
We also used immunocytochemistry to analyze nerve injury-induced changes in substance P (SP) and NK-1 (SP) receptor expression in the spinal cord.
Gene_expression (expression) of SP in nerve associated with nervous system injury, spinal cord and substance p
7) Confidence 0.26 Published 1998 Journal Pain Section Abstract Doc Link 9696476 Disease Relevance 1.28 Pain Relevance 1.05
These include Olig3, Neurog2(Ngn2), Ascl1(Mash1), Gsh1, Gsh2, Math1, Pax3, Pax7, and Ptf1a.
Gene_expression (include) of Pax3
8) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
Pax-3 was found upstream of the following transcripts: prion protein (prnp), cathepsin L (ctsl), stromal cell derived factor receptor 1 (sdfr1) [31], thrombospondin, type I domain containing 6 (thsd6), and uroplakin 1b (upk1b).
Gene_expression (found) of Pax-3 in stromal cell
9) Confidence 0.21 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.47 Pain Relevance 0
Therefore, our data suggests that Pax-3-regulated suppression of neural development in control detrusor changed substantially during inflammation and genes involved in neuronal development such as syn were found to be up-regulated.
Gene_expression (suppression) of Pax-3-regulated in neural associated with inflammation and overactive bladder
10) Confidence 0.21 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.70 Pain Relevance 0.05
In addition to Pax-3, other TREs such as: PITX2, CDP, and c-Myb were also found over-represented (figure 5).
Gene_expression (represented) of Pax-3
11) Confidence 0.21 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.49 Pain Relevance 0
METHODS: Using retrograde neuronal tracing in combination with double-labelling immunohistochemistry, SP, trkA- and TRPV1-receptor expression was examined in airway-specific sensory neurons of BALB/c mice before and after NGF treatment.
Gene_expression (expression) of SP in sensory neurons
12) Confidence 0.21 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15347383 Disease Relevance 0 Pain Relevance 0
However, both expression of both skeletal myogenic (except for Pax3) and cardio myogenic (except for Nkx2-5) markers can be seen after solo Sk-34 cell culture, and expression of all 6 cardio myogenic markers was seen after co-culture with rat embryonic cardiomyocytes.
Gene_expression (expression) of Pax3 in cardiomyocytes
13) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.07 Pain Relevance 0
Different temporal phases between SP- and glutamate-driven feed-forward inhibition
Gene_expression (phases) of SP associated with glutamate and substance p
14) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.34 Pain Relevance 1.12
Functional significance of SP-driven feed-forward inhibition
Gene_expression (significance) of SP associated with substance p
15) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.12 Pain Relevance 0.91
One possible explanation for these inconsistent results is that SP may produce mixed effects in sensory-related transmission and modulation.
Gene_expression (produce) of SP associated with substance p
16) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.36 Pain Relevance 1.57
Mice genetically engineered not to express the precursor of SP [4] and mice that do not express SP's target, the NK1R [3], both display reduced responses to painful stimuli.
Gene_expression (express) of SP associated with pain and substance p
17) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.33 Pain Relevance 1.20
Mice genetically engineered not to express the precursor of SP [4] and mice that do not express SP's target, the NK1R [3], both display reduced responses to painful stimuli.
Neg (not) Gene_expression (express) of SP associated with pain and substance p
18) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.33 Pain Relevance 1.21
RESULTS: NGF injected into the lower airway was able to induce SP (13.0+/-2.03% vs. 5.9+/-0.33%) and trkA expression (78+/-2.66% vs. 60+/-2.11%) in larger diameter (>25 microm), capsaicin-insensitive and trkA-positive vagal sensory neurons that were retrograde-labelled with Fast Blue dye from the main stem bronchi.
Gene_expression (expression) of SP in stem
19) Confidence 0.19 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15347383 Disease Relevance 0 Pain Relevance 0
We found that NGF, SP, and calcitonin gene-related peptide gene expression is upregulated in the dorsal root ganglion (DRG) of db/db mice before or during the period that they develop mechanical allodynia.
Gene_expression (expression) of SP in DRG associated with ganglion cysts, dorsal root ganglion, allodynia, nerve growth factor and calcitonin gene-related peptide
20) Confidence 0.18 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19816194 Disease Relevance 1.20 Pain Relevance 1.06

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