INT14627

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Context Info
Confidence 0.08
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.14
Pain Relevance 5.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3, Pax3) nucleus (Pax3, Pax3) DNA binding (Pax3, Pax3)
Anatomy Mention Frequency
spinal cord 1
brain 1
Pax3 (Mus musculus)
Pax3 (Mus musculus)
Pain Term Frequency Confidence Heat
substance P 587 100.00 Very High Very High Very High
Opioid 5 99.80 Very High Very High Very High
Spinal cord 9 98.56 Very High Very High Very High
cytokine 20 96.16 Very High Very High Very High
opiate 3 94.36 High High
Calcitonin gene-related peptide 3 94.28 High High
Neuropeptide 5 91.84 High High
Potency 6 82.00 Quite High
Inflammation 15 58.80 Quite High
imagery 2 50.00 Quite Low
Disease Term Frequency Confidence Heat
Targeted Disruption 42 100.00 Very High Very High Very High
Immunization 4 97.84 Very High Very High Very High
Granuloma 92 97.76 Very High Very High Very High
Bronchospasm 1 75.00 Quite High
Asthma 1 62.88 Quite High
INFLAMMATION 12 58.80 Quite High
Infection 12 50.00 Quite Low
Anaplastic Astrocytoma 1 22.52 Low Low
Schistosomiasis 2 11.72 Low Low
Communicable Diseases 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the reduction of SP-induced caudally directed biting and scratching behaviors as an index of biological activity, 3H-SP(1-7) was shown to be equipotent to unlabeled SP(1-7). 3H-SP(1-7) was found to bind reversibly to a saturable population of sites.
SP Binding (bind) of SP associated with substance p
1) Confidence 0.08 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1700082 Disease Relevance 0 Pain Relevance 0.84
A tritium-labeled aminoterminal heptapeptide of SP, 3H-SP(1-7), was synthesized, purified, and used to characterize the binding of a variety of fragments of SP and opioids in the mouse brain and spinal cord membranes.
SP Binding (binding) of SP in spinal cord associated with opioid, spinal cord and substance p
2) Confidence 0.08 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1700082 Disease Relevance 0 Pain Relevance 0.86
A tritium-labeled aminoterminal heptapeptide of SP, 3H-SP(1-7), was synthesized, purified, and used to characterize the binding of a variety of fragments of SP and opioids in the mouse brain and spinal cord membranes.
SP Binding (binding) of SP in brain associated with opioid, spinal cord and substance p
3) Confidence 0.03 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1700082 Disease Relevance 0 Pain Relevance 0.86
However, since NK1 binds only SP and not neurokinin A and the results in NK1-knockout mice mirror the findings in SP-knockout mice, we are confident in attributing reduced granuloma formation and proinflammatory cytokine production to the absence of SP signaling and not to reduced or absent neurokinin A signaling.
SP Binding (binds) of SP associated with targeted disruption, granuloma, cytokine and substance p
4) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817809 Disease Relevance 0.77 Pain Relevance 0.79
Two-way analysis of variance followed by Student-Newman-Keuls test showed that there was a dose-dependent effect (p < 0.001) on the binding of unlabeled SP and the SP analogs to the rSPR.
SP Binding (binding) of SP associated with substance p
5) Confidence 0.00 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.91
Sigmoidal (Hill, 3 parameter) regression was then performed on the data to determine the IC50, the concentration of fluorescent analog required to inhibit the binding of radiolabeled SP by 50 %, for each SP analog.


SP Binding (binding) of SP associated with substance p
6) Confidence 0.00 Published 2001 Journal BMC Chem Biol Section Body Doc Link PMC33344 Disease Relevance 0 Pain Relevance 0.50
In this system, the relative affinity of the alpha-SP Ab, at dilutions of 1 in 5,000 and 1 in 10,000, was about 50 times greater for SP than NKA.
SP Binding (affinity) of SP associated with substance p
7) Confidence 0.00 Published 1995 Journal Life Sci. Section Abstract Doc Link 7541500 Disease Relevance 0.37 Pain Relevance 1.06

General Comments

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