INT146279

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX4) transport (P2RX4) plasma membrane (P2RX4)
response to stress (P2RX4)
Anatomy Link Frequency
macrophage 2
P2RX4 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 1 78.48 Quite High
Pain 1 75.88 Quite High
Neuropathic pain 1 70.84 Quite High
IPN 1 63.60 Quite High
cytokine 1 59.96 Quite High
Disease Link Frequency Relevance Heat
Pain 1 75.88 Quite High
Neuropathic Pain 2 70.84 Quite High
Inflammatory Pain 1 63.60 Quite High
Apoptosis 1 60.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, classical activation of macrophage for 48 h with IFN-gamma and TNF-alpha or IFN-gamma and LPS reduced surface and functional P2X(4)R expression by 3-fold without altering total P2X(4)R protein levels.
Negative_regulation (reduced) of Gene_expression (expression) of P2X in macrophage
1) Confidence 0.46 Published 2009 Journal Eur. J. Immunol. Section Abstract Doc Link 19283779 Disease Relevance 0.13 Pain Relevance 0.06
Coexpression of a dominant-negative P2X4 mutant (C353W) with P2X7, inhibited P2X7 receptor mediated currents by greater than 2-fold, whereas a nonfunctional but non-dominant-negative mutant (S341W) did not.
Negative_regulation (inhibited) of Gene_expression (Coexpression) of P2X4
2) Confidence 0.35 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17785580 Disease Relevance 0.21 Pain Relevance 0.22

General Comments

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