INT146283

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (ERLIN1)
Anatomy Link Frequency
central nervous system 1
ERLIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Codeine 3 10.00 Low Low
Central nervous system 9 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Unconsciousness 6 56.72 Quite High
Acid Reflux 3 38.36 Quite Low
Body Weight 9 5.00 Very Low Very Low Very Low
Sleep Disorders 6 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Two modeling approaches to the miotic effects of dihydrocodeine provided similar transfer half-lives between plasma and effect site, which also agreed with previous independently estimated values obtained from analgesic effects, suggesting that pupil size is a valid biomarker to estimate the value of ke0 for opioid central nervous system (CNS) effects.


Regulation (value) of ke0 in central nervous system
1) Confidence 0.22 Published 2007 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 17786418 Disease Relevance 0 Pain Relevance 0
For analysis of data for a known LOR time, we obtained the predicted effect-site concentration for particular values of ke0 by re-run of the STANPUMP.
Regulation (values) of ke0
2) Confidence 0.03 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872834 Disease Relevance 0 Pain Relevance 0
Lim [13] demonstrated a novel method of deriving the ke0 for propofol in the conventional three-compartment model of Marsh et al. [14], and found that the value of ke0 was 0.80/min.
Regulation (value) of ke0
3) Confidence 0.03 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872834 Disease Relevance 0.06 Pain Relevance 0
If inadequate values of ke0 were applied, the effect site concentrations would be predicted as either higher or lower than the 'real' concentration of the effect site.
Regulation (values) of ke0
4) Confidence 0.03 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872834 Disease Relevance 0 Pain Relevance 0

General Comments

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