INT146339

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.76
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
plasma 2
spinal cord 1
IB4 1
lung 1
Cxcl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 20 100.00 Very High Very High Very High
Spinal cord 12 97.96 Very High Very High Very High
Hyperalgesia 25 97.32 Very High Very High Very High
Action potential 34 97.20 Very High Very High Very High
Inflammation 72 94.96 High High
cytokine 53 93.92 High High
metalloproteinase 29 85.60 High High
Perioperative pain 2 75.00 Quite High
Nav1.9 6 65.00 Quite High
Inflammatory mediators 13 64.96 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 25 97.32 Very High Very High Very High
Apoptosis 5 93.88 High High
Necrosis 13 93.32 High High
Neurodegenerative Disease 3 89.24 High High
Cancer 5 86.12 High High
INFLAMMATION 88 75.00 Quite High
Death 12 75.00 Quite High
Post Operative Pain 2 75.00 Quite High
Injury 17 71.20 Quite High
Hepatotoxicity 10 69.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a second group of rats, plasma and spinal cord samples collected after three and six weeks of placebo or stavudine administration were examined for changes in CINC-1, IL-6, adiponectin (plasma only) and lactate (plasma only) concentration.
Spec (examined) Regulation (changes) of CINC-1 in spinal cord associated with spinal cord
1) Confidence 0.43 Published 2009 Journal Neurotoxicology Section Abstract Doc Link 19442827 Disease Relevance 1.02 Pain Relevance 0.73
As shown in Table 2, the overall effect of GRO/KC treatment was a marked increase in excitability, including a reduced action potential threshold, depolarized resting potential, and decreased rheobase which were observed in both IB4-negative and IB4-positive cells.
Regulation (effect) of GRO/KC in IB4 associated with action potential
2) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.21
In the case of multiple comparisons over a voltage range for activation data, the data were analyzed by two-way repeated measures ANOVA (RM ANOVA), with pairwise multiple comparison (Holm-Sidak method) to determine at which voltages the differences between experimental and control cells were significant if an overall effect of GRO/KC treatment was observed.
Regulation (effect) of GRO/KC
3) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0
Stavudine administration did not affect the plasma concentration of IL-6, CINC-1, adiponectin or lactate.
Neg (not) Regulation (affect) of CINC-1 in plasma
4) Confidence 0.26 Published 2009 Journal Neurotoxicology Section Abstract Doc Link 19442827 Disease Relevance 0.87 Pain Relevance 0.91
The tissue concentrations of IL-1beta, IL-6, and CINC-1 increased within 24 h of surgery, and TNF-alpha concentration increased within 48 h of surgery.
Regulation (concentrations) of CINC-1
5) Confidence 0.23 Published 2007 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 17823623 Disease Relevance 0.72 Pain Relevance 0.80
In a second group of rats, plasma and spinal cord samples collected after three and six weeks of placebo or stavudine administration were examined for changes in CINC-1, IL-6, adiponectin (plasma only) and lactate (plasma only) concentration.
Spec (examined) Regulation (changes) of CINC-1 in plasma associated with spinal cord
6) Confidence 0.14 Published 2009 Journal Neurotoxicology Section Abstract Doc Link 19442827 Disease Relevance 1.02 Pain Relevance 0.73
Upregulation of PMN chemokines (CINC-1 and MIP2) was similar between the TNF?
Regulation (Upregulation) of CINC-1 associated with chemokine
7) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000109 Disease Relevance 0.07 Pain Relevance 0.08
These kinase inhibitors alone had little effect on CINC levels in the lung tissue and lavage fluid.
Neg (little) Regulation (effect) of CINC in lung
8) Confidence 0.08 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.06 Pain Relevance 0.19

General Comments

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