INT14634

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Context Info
Confidence 0.52
First Reported 1990
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.89
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Sqle) endoplasmic reticulum (Sqle)
Anatomy Link Frequency
lymph nodes 1
Sqle (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Demyelination 3 99.62 Very High Very High Very High
peripheral neuropathy 1 79.28 Quite High
induced neuropathy 2 75.00 Quite High
Sciatic nerve 2 70.32 Quite High
anesthesia 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 4 99.62 Very High Very High Very High
Neuropathic Pain 3 84.96 Quite High
Repression 1 81.60 Quite High
Peripheral Neuropathy 1 79.28 Quite High
Hyperplasia 1 66.24 Quite High
Poisoning 3 59.52 Quite High
Fever 1 50.00 Quite Low
Body Temperature Changes 1 48.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have now demonstrated directly specificity for squalene epoxidase; our in vitro studies show that squalene epoxidase is inhibited 50% in the presence of 5 microM tellurite, the presumptive in vivo active metabolite.
Negative_regulation (inhibited) of squalene epoxidase
1) Confidence 0.52 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7722502 Disease Relevance 0.38 Pain Relevance 0.14
The demyelination is related to the inhibition of squalene epoxidase activity, which results in a block in cholesterol synthesis and accumulation of squalene.
Negative_regulation (inhibition) of epoxidase associated with demyelination
2) Confidence 0.13 Published 1990 Journal J. Neurosci. Res. Section Abstract Doc Link 1700139 Disease Relevance 0.51 Pain Relevance 0.25
A pronounced signal reduction was observed in the mesenteric (PD-SE = 20 +/- 6%, T2* GRE = 55 +/- 19%), iliac (PD-SE = 13 +/- 13%, T2* GRE = 44 +/- 24%), and popliteal (PD-SE = 24 +/- 7%, T2* GRE = 70 +/- 11%) lymph nodes and only a moderate reduction in the mandibular (PD-SE = 4 +/- 7%, T2* GRE = 42 +/- 15%), axillary (PD-SE = 0 +/- 4%, T2* GRE = 8 +/- 7%), and inguinal (PD-SE = 5 +/- 5%, T2* GRE = 34 +/- 18%) lymph nodes.
Negative_regulation (reduction) of PD-SE in lymph nodes
3) Confidence 0.05 Published 1996 Journal Acad Radiol Section Body Doc Link 8796730 Disease Relevance 0 Pain Relevance 0

General Comments

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