INT146344

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.17
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
substantia nigra 2
Slc6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 29 100.00 Very High Very High Very High
Substantia nigra 3 96.60 Very High Very High Very High
monoamine 2 90.48 High High
dopamine receptor 3 65.12 Quite High
Eae 4 45.60 Quite Low
Serotonin 4 42.56 Quite Low
Enkephalin 1 25.00 Low Low
fluoxetine 6 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 72 99.88 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 17 95.56 Very High Very High Very High
Stress 2 89.20 High High
Cognitive Disorder 6 76.96 Quite High
Toxicity 3 75.44 Quite High
Disease 1 60.68 Quite High
Schizophrenia 2 59.84 Quite High
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tamoxifen at 50 microg reduced the methamphetamine effect on striatal dopamine concentration, dopamine transporter specific binding and prevented the increase in preproenkephalin mRNA levels; in the substantia nigra tamoxifen prevented the decrease of dopamine transporter mRNA levels.
Negative_regulation (reduced) of Regulation (effect) of dopamine transporter in substantia nigra associated with dopamine and substantia nigra
1) Confidence 0.32 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17825264 Disease Relevance 0.22 Pain Relevance 0.62
DAT-KO mice lack a key target of AMPH, the DA transporter [21]; thus, it is likely that AMPH exerts a calming effect via serotonergic mechanisms [23], [24].
Negative_regulation (lack) of Regulation (target) of DA transporter associated with targeted disruption and dopamine
2) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668764 Disease Relevance 0.95 Pain Relevance 0.08

General Comments

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