INT146346

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 11.76
Pain Relevance 8.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpa1) transmembrane transport (Trpa1)
Anatomy Link Frequency
neurons 10
visceral 2
sensory neurons 2
spinal cord segments 2
IB4 2
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 40 100.00 Very High Very High Very High
nociceptor 134 99.98 Very High Very High Very High
nud 2 99.36 Very High Very High Very High
chronic construction injury 174 99.28 Very High Very High Very High
Pain 168 99.12 Very High Very High Very High
intrathecal 2 99.04 Very High Very High Very High
dorsal root ganglion 107 98.88 Very High Very High Very High
Mechanotransduction 22 98.88 Very High Very High Very High
allodynia 174 98.80 Very High Very High Very High
tetrodotoxin 3 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 405 99.72 Very High Very High Very High
Nervous System Injury 141 99.56 Very High Very High Very High
Dyspepsia 2 99.36 Very High Very High Very High
Pain 158 99.12 Very High Very High Very High
Ganglion Cysts 137 98.88 Very High Very High Very High
Neuropathic Pain 371 98.80 Very High Very High Very High
Cold Sores 136 98.78 Very High Very High Very High
Colitis 60 97.56 Very High Very High Very High
INFLAMMATION 172 97.28 Very High Very High Very High
Pancreatitis 5 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently to TRPA1 antisense oligodeoxynucleotide treatment there was a marked decrease of the expression of TRPA1 receptor in both sciatic nervous and spinal cord segments.
Negative_regulation (decrease) of Gene_expression (expression) of TRPA1 in spinal cord segments associated with spinal cord
1) Confidence 0.59 Published 2008 Journal Neuroscience Section Abstract Doc Link 18272293 Disease Relevance 0.48 Pain Relevance 0.90
Interestingly, we observed that TRPA1 was predominantly expressed in IB4 positive neurons and that it was in this population of neurons that TRPA1 expression was lost after injury.
Negative_regulation (lost) of Gene_expression (expression) of TRPA1 in neurons associated with injury
2) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.78 Pain Relevance 0.46
Previous studies have demonstrated that IB4 binding is strongly reduced in injured neurons following SNL in the rat [41] suggesting that loss of this population contributes to the reduction in TRPA1 expression.
Negative_regulation (reduction) of Gene_expression (expression) of TRPA1 in neurons associated with eae
3) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.75 Pain Relevance 0.43
However, using real time RT-PCR, we showed that TRPA1 expression was reduced drastically in both E-CKO mice and L-CKO mice (See Additional file 2).
Negative_regulation (reduced) of Gene_expression (expression) of TRPA1
4) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.06 Pain Relevance 0.38
nociceptors treated with the TRPA1 antagonist showed no change in mechanical firing, A?
Negative_regulation (treated) of Gene_expression (antagonist) of TRPA1 in nociceptors associated with antagonist and nociceptor
5) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2681449 Disease Relevance 0.49 Pain Relevance 0.77
Deletion of trpv4 or trpa1 suppressed c-Fos expression and pain behavior, and deletion of trpa1 attenuated pancreatitis.
Negative_regulation (suppressed) of Gene_expression (Deletion) of trpa1 associated with pain and pancreatitis
6) Confidence 0.43 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20539005 Disease Relevance 1.59 Pain Relevance 1.34
RT-PCR analysis revealed the expression of TRPA1 and TRPV1, but not TRPM8, throughout the mouse intestine.
Negative_regulation (revealed) of Gene_expression (expression) of TRPA1 in intestine
7) Confidence 0.42 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17825279 Disease Relevance 0 Pain Relevance 0.57
Here, we investigated the role of TRPA1 in generation of mechanically-activated currents in the plasma membrane of isolated DRG neurons from adult mice using a dual approach: genetic ablation of TRPA1 and acute pharmacological inhibition of TRPA1.
Negative_regulation (inhibition) of Gene_expression (ablation) of TRPA1 in neurons associated with dorsal root ganglion
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922334 Disease Relevance 0.32 Pain Relevance 0.24
Here, we investigated the role of TRPA1 in generation of mechanically-activated currents in the plasma membrane of isolated DRG neurons from adult mice using a dual approach: genetic ablation of TRPA1 and acute pharmacological inhibition of TRPA1.
Negative_regulation (inhibition) of Gene_expression (ablation) of TRPA1 in neurons associated with dorsal root ganglion
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922334 Disease Relevance 0.32 Pain Relevance 0.24
In the pathological condition, the expression of TRPV3, TRPV4, TRPM5, and TRPA1 was markedly reduced and took a long time to recover.
Negative_regulation (reduced) of Gene_expression (expression) of TRPA1
10) Confidence 0.41 Published 2010 Journal Acta Oto-Laryngologica Section Abstract Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.04
In the pathological condition, the expression of TRPV3, TRPV4, TRPM5, and TRPA1 was markedly reduced and recovery took a long time.
Negative_regulation (reduced) of Gene_expression (expression) of TRPA1
11) Confidence 0.41 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0.13
We therefore examined TRPM8 and TRPA1 expression in the rat after CCI injury.
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of TRPA1 associated with injury and chronic construction injury
12) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.88 Pain Relevance 0.16
Intriguingly the reduction in TRPA1 expression was seen exclusively in the IB4-positive neurons, with no change in the number of TRPA1 plus CGRP or TRPA1 plus NF200 positive cells (Table 2).
Negative_regulation (reduction) of Gene_expression (expression) of TRPA1 in IB4 associated with calcitonin gene related peptide
13) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.52 Pain Relevance 0.41
We therefore examined gross expression levels of TRPM8 and TRPA1 mRNA in DRG of injured neurons using qRT-PCR.
Spec (examined) Negative_regulation (levels) of Spec (examined) Gene_expression (expression) of TRPA1 mRNA in neurons
14) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.08 Pain Relevance 0.33
TRPA1 mRNA expression was also significantly reduced following nerve injury (Table 2).
Negative_regulation (reduced) of Gene_expression (expression) of TRPA1 mRNA in nerve associated with nervous system injury
15) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.52 Pain Relevance 0.42
To elucidate the roles of the hot and cold thermoreceptors in sensory neurons, we first assessed TRPV1, TRPM8, and TRPA1 mRNA expression in rat and mouse peripheral tissues.
Negative_regulation (assessed) of Gene_expression (expression) of TRPA1 mRNA in sensory neurons
16) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.26 Pain Relevance 0.84
Quantification of band density revealed a 59% knockdown of TrpV1 protein in animals injected with HSV-GFP-miR-TRPV1 compared to the negative control, whereas the levels of TrpA1 and Stat1 were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (levels) of TrpA1 in band associated with cold sores
17) Confidence 0.35 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 1.35 Pain Relevance 0.38
Intrathecal injection of TRPA1 antisense oligonucleotides, reduces TRPA1 expression and attenuates visceral hyperalgesia following TNBS-induced colitis [54].
Negative_regulation (reduces) of Gene_expression (expression) of TRPA1 in visceral associated with colitis, nud and intrathecal
18) Confidence 0.18 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.36 Pain Relevance 0.80

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