INT146347

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 6.96
Pain Relevance 5.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Anatomy Link Frequency
sensory neurons 4
neurons 2
trigeminal nerve 2
intestine 2
Trpm8 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 13 100.00 Very High Very High Very High
chronic construction injury 87 99.28 Very High Very High Very High
Inflammation 43 99.16 Very High Very High Very High
fifth nerve 4 99.16 Very High Very High Very High
allodynia 105 98.80 Very High Very High Very High
tetrodotoxin 2 98.76 Very High Very High Very High
agonist 67 97.96 Very High Very High Very High
induced neuropathy 9 96.40 Very High Very High Very High
Potency 4 96.12 Very High Very High Very High
trigeminal ganglion 97 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 78 99.80 Very High Very High Very High
Injury 209 99.28 Very High Very High Very High
INFLAMMATION 44 99.16 Very High Very High Very High
Hypersensitivity 41 99.10 Very High Very High Very High
Neuropathic Pain 212 98.80 Very High Very High Very High
Brain Injury 4 97.16 Very High Very High Very High
Loss Of Sense Of Smell 8 96.16 Very High Very High Very High
Ganglion Cysts 137 95.44 Very High Very High Very High
Pain 180 94.56 High High
Nociception 80 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The other interesting results were that expression of TRPM8 was not reduced following methimazole treatment.
Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of TRPM8
1) Confidence 0.55 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.76 Pain Relevance 0.09
From our results we are unable to identify the central mechanism of cold hypersensitivity, however it is interesting that we observed decreases in TRPM8 expression.
Negative_regulation (decreases) of Gene_expression (expression) of TRPM8 associated with hypersensitivity
2) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.98 Pain Relevance 0.90
An injection of oxaliplatin increased the expression level of TRPM8 mRNA at day 3 after injection and the expression was decreased to the near-normal level on days 10 and 25.
Negative_regulation (decreased) of Gene_expression (expression) of TRPM8 mRNA
3) Confidence 0.43 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19375484 Disease Relevance 0.46 Pain Relevance 0.54
Is TRPM8 responsible for the analgesic effect produced by cold or chemical cooling compounds?
Negative_regulation (effect) of Gene_expression (responsible) of TRPM8 associated with analgesic
4) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC1988789 Disease Relevance 0.44 Pain Relevance 0.18
Overall, our data suggest a sequential model of TRPM8 gating where chemical modulators can favour (e.g. menthol) or hinder (e.g.
Negative_regulation (model) of Gene_expression (gating) of TRPM8
5) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0 Pain Relevance 0.18
RT-PCR analysis revealed the expression of TRPA1 and TRPV1, but not TRPM8, throughout the mouse intestine.
Negative_regulation (revealed) of Gene_expression (expression) of TRPM8 in intestine
6) Confidence 0.41 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17825279 Disease Relevance 0 Pain Relevance 0.57
It is plausible that menthol and/or curry odors stimulate the trigeminal nerve system, although the present study found unreduced expression of TRPM8 or early recovery of TRPV1 in the ORNs.
Negative_regulation (unreduced) of Gene_expression (expression) of TRPM8 in trigeminal nerve associated with fifth nerve
7) Confidence 0.40 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.12 Pain Relevance 0.21
We therefore examined TRPM8 and TRPA1 expression in the rat after CCI injury.
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of TRPM8 associated with injury and chronic construction injury
8) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.88 Pain Relevance 0.16
We therefore examined gross expression levels of TRPM8 and TRPA1 mRNA in DRG of injured neurons using qRT-PCR.
Spec (examined) Negative_regulation (levels) of Spec (examined) Gene_expression (expression) of TRPM8 in neurons
9) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.07 Pain Relevance 0.33
To elucidate the roles of the hot and cold thermoreceptors in sensory neurons, we first assessed TRPV1, TRPM8, and TRPA1 mRNA expression in rat and mouse peripheral tissues.
Negative_regulation (assessed) of Gene_expression (expression) of TRPM8 in sensory neurons
10) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.26 Pain Relevance 0.84
Expression of TrpM8 was undetectable, and Mrgprd, Mrgpra1, and Scn11a were markedly reduced.
Negative_regulation (undetectable) of Gene_expression (Expression) of TrpM8
11) Confidence 0.30 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.46 Pain Relevance 1.03
Interestingly, TRPM8 is expressed in a subset of sensory neurons of C and A?
Negative_regulation (subset) of Gene_expression (expressed) of TRPM8 in sensory neurons
12) Confidence 0.24 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.53 Pain Relevance 0.41

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