INT146350

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Context Info
Confidence 0.80
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.79
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome segregation (Rgs14) cytoplasm (Rgs14) mitosis (Rgs14)
signal transduction (Rgs14) nucleocytoplasmic transport (Rgs14) nucleus (Rgs14)
Anatomy Link Frequency
gray matter 2
Rgs14 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 21 100.00 Very High Very High Very High
Central grey 6 99.36 Very High Very High Very High
opioid receptor 21 98.96 Very High Very High Very High
tolerance 6 98.04 Very High Very High Very High
antinociception 3 94.72 High High
Antinociceptive 3 91.28 High High
Opioid 3 82.68 Quite High
mu opioid receptor 3 75.00 Quite High
MU agonist 3 74.36 Quite High
Pain 9 25.00 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 9 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in morphine-activated MORs the RGS14 prevents GRKs from phosphorylating those residues required for beta-arresting-mediated endocytosis.
Phosphorylation (phosphorylating) of RGS14 associated with morphine
1) Confidence 0.80 Published 2007 Journal Cell. Signal. Section Abstract Doc Link 17825524 Disease Relevance 0.24 Pain Relevance 1.32
The regulator of G-protein signaling, the RGS14 protein, associates with MORs in periaqueductal gray matter (PAG) neurons, and when RGS14 is silenced morphine increased the serine 375 phosphorylation in the C terminus of the MOR, a GRK substrate.
Phosphorylation (phosphorylation) of RGS14 in gray matter associated with urological neuroanatomy, opioid receptor, central grey and morphine
2) Confidence 0.61 Published 2007 Journal Cell. Signal. Section Abstract Doc Link 17825524 Disease Relevance 0.27 Pain Relevance 1.23
The regulator of G-protein signaling, the RGS14 protein, associates with MORs in periaqueductal gray matter (PAG) neurons, and when RGS14 is silenced morphine increased the serine 375 phosphorylation in the C terminus of the MOR, a GRK substrate.
Phosphorylation (phosphorylation) of RGS14 in gray matter associated with urological neuroanatomy, opioid receptor, central grey and morphine
3) Confidence 0.61 Published 2007 Journal Cell. Signal. Section Abstract Doc Link 17825524 Disease Relevance 0.27 Pain Relevance 1.23

General Comments

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