INT14637

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Context Info
Confidence 0.43
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 7.06
Pain Relevance 7.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MBP)
Anatomy Link Frequency
nodes 2
corpus callosum 2
blood 1
glial cells 1
CSF 1
MBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Demyelination 37 99.60 Very High Very High Very High
Pain 451 99.08 Very High Very High Very High
dorsal root ganglion 1 99.00 Very High Very High Very High
cocaine 144 97.98 Very High Very High Very High
Dynorphin 2 96.48 Very High Very High Very High
Nav1.7 425 95.68 Very High Very High Very High
Central nervous system 21 93.84 High High
Clonidine 8 92.44 High High
sodium channel 85 91.76 High High
Neuropathic pain 57 89.12 High High
Disease Link Frequency Relevance Heat
Demyelinating Disease 72 99.60 Very High Very High Very High
Ganglion Cysts 8 99.00 Very High Very High Very High
Congenital Anomalies 15 98.80 Very High Very High Very High
Disease 102 97.84 Very High Very High Very High
Cancer 13 97.76 Very High Very High Very High
Shock 12 96.80 Very High Very High Very High
Neurological Disease 2 95.96 Very High Very High Very High
Alzheimer's Dementia 4 95.48 Very High Very High Very High
Natriuresis 4 94.60 High High
Injury 6 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, the relative area of PGP 9.5 positive and MBP positive was 7.0 ± 3.0 percent compared to PGP 9.5 negative and MBP positive 5.9 ± 1.3 percent, (P > .7, n = 3 determinations from 10 distinct patients).
Negative_regulation (positive) of MBP
1) Confidence 0.43 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
These focal deposits of MBP were demonstrated as both intracellular MBP as well as extracellularly released MBP (vide infra).
Negative_regulation (deposits) of MBP
2) Confidence 0.43 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
The dominant epitope of CSF MBPLM is in the decapeptide of 80-89 from the intact MBP molecule of 170 residues.
Negative_regulation (epitope) of MBP in CSF
3) Confidence 0.42 Published 1998 Journal Mult. Scler. Section Abstract Doc Link 9532587 Disease Relevance 0.31 Pain Relevance 0.22
Generalized loss was seen in some fibers with typical nodes (Fig. 5B), while localized alterations included a loss of MBP in the area adjacent to heminodes (Fig. 5B) and the axonal region between split nodes (Fig. 5C).
Negative_regulation (loss) of MBP in nodes
4) Confidence 0.38 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0.07 Pain Relevance 0.67
This pattern of MBP staining loss is similar to that found in demyelinating diseases [8] and this finding suggests the reorganization of NaChs at demyelinated sites as a pulpal pain mechanism.
Negative_regulation (loss) of MBP associated with pain and demyelinating disease
5) Confidence 0.38 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0.65 Pain Relevance 1.05
These findings are consistent with a remodeling of NaChs in areas of demyelination as identified by a loss of MBP staining.


Negative_regulation (loss) of MBP associated with demyelination
6) Confidence 0.38 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0.10 Pain Relevance 0.69
Typical and atypical nodes that were associated with a generalized loss of MBP staining (Fig. 5B) and the axonal area located between the split nodes (Fig. 5C), both contained prominent Nav1.7-immunofluorescence.
Negative_regulation (loss) of MBP in nodes associated with nav1.7
7) Confidence 0.38 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0.08 Pain Relevance 0.74
The magnitudes of increased ANF and decreased Vas were correlated with the decreased MBP (r = -0.57 and 0.53, respectively, P < 0.05).
Negative_regulation (decreased) of MBP
8) Confidence 0.36 Published 1993 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 7901963 Disease Relevance 0.25 Pain Relevance 0.42
Additionally, the atypical nodal sites were more common in painful samples and were associated with areas where MBP staining was lost.
Negative_regulation (lost) of MBP associated with pain
9) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0.58 Pain Relevance 0.98
After the treatment, mean blood pressure (MBP), heart rate and 24 h urine norepinephrine, epinephrine were decreased, but no change was found in plasma Dyn A.
Negative_regulation (decreased) of MBP in urine
10) Confidence 0.31 Published 1993 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 7901963 Disease Relevance 0.26 Pain Relevance 0.43
A bolus of human UII (0.03 nmol/kg) caused a decrease of heart rate (HR) (13%), mean blood pressure (MBP) (18%), and first-order derivative of left ventricular pressure (dP/dt) (11%).
Negative_regulation (decrease) of MBP in blood
11) Confidence 0.30 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14615276 Disease Relevance 0.37 Pain Relevance 0
We propose that such an effect is mediated by the altered proteasome-dependent production of a specific MBP epitope presented on the MHC class I.
Negative_regulation (epitope) of MBP
12) Confidence 0.21 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2823778 Disease Relevance 0.19 Pain Relevance 0
Both signatures included a number of genes (MBP, MOBP, MAG, OLIG1, and OLIG2) previously found in glial cells, several of which have been linked to neurological diseases.
Negative_regulation (number) of MBP in glial cells associated with neurological disease
13) Confidence 0.15 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.73 Pain Relevance 0.17
Significant decrease in the amount of myelin basic protein has been reported in the white matter of Alzheimer’s disease patients, accompanied by increased quantities of b-amyloid peptides (21).
Negative_regulation (decrease) of myelin basic protein in white matter associated with alzheimer's dementia and disease
14) Confidence 0.13 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.81 Pain Relevance 0
Deposition of MBP+ granules was also observed in the the vicinity of the tumour mass.
Negative_regulation (Deposition) of MBP associated with cancer
15) Confidence 0.07 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.46 Pain Relevance 0
The only laboratory test which was associated with a benign prognosis was the absence of CSF myelin basic protein in remission.
Negative_regulation (absence) of basic protein
16) Confidence 0.05 Published 1986 Journal Q. J. Med. Section Abstract Doc Link 2422674 Disease Relevance 0.75 Pain Relevance 0.23
In support of the potentially deleterious action of cocaine on white matter, using a rat model of chronic (28-day) cocaine administration, Narayana et al. [69] recently showed lower FA in cocaine-treated compared to saline-treated rats in the posterior corpus callosum along with a corresponding reduction in myelin basic protein.
Negative_regulation (reduction) of basic protein in corpus callosum associated with cocaine
17) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905416 Disease Relevance 0.16 Pain Relevance 0.47
This is consistent with the finding of a forty-percent reduction in myelin basic protein in the corpus callosum of rats exposed chronically to cocaine [69].
Negative_regulation (reduction) of basic protein in corpus callosum associated with cocaine
18) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905416 Disease Relevance 0.05 Pain Relevance 0.33
In contrast, steady-state levels of mRNA, determined by Northern blot analysis, for P0 and myelin basic protein were markedly decreased (levels after 5 days of tellurium exposure were only 10-15% of control levels as a fraction of total RNA and 25-35% of control levels when the increased levels of total RNA were taken into account).
Negative_regulation (decreased) of basic protein
19) Confidence 0.02 Published 1990 Journal J. Neurosci. Res. Section Abstract Doc Link 1700139 Disease Relevance 0.45 Pain Relevance 0.22
LPA also caused a down-regulation of myelin proteins, such as myelin basic protein (MBP) and myelin protein zero (MPZ) to approximately 70% of control.
Negative_regulation (regulation) of basic protein
20) Confidence 0.01 Published 2007 Journal Neurochem. Int. Section Abstract Doc Link 17056157 Disease Relevance 0.77 Pain Relevance 0.55

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