INT146373

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.39
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cysltr1) plasma membrane (Cysltr1) signal transducer activity (Cysltr1)
Anatomy Link Frequency
spike 4
dendrites 2
synapses 2
Cysltr1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 442 100.00 Very High Very High Very High
Glutamate receptor 43 99.52 Very High Very High Very High
Spinal cord 8 99.24 Very High Very High Very High
Anterior cingulate cortex 68 98.44 Very High Very High Very High
Nucleus accumbens 3 98.44 Very High Very High Very High
long-term potentiation 65 97.40 Very High Very High Very High
Hippocampus 23 95.40 Very High Very High Very High
nMDA receptor antagonist 1 92.92 High High
Pyramidal cell 19 90.88 High High
Neuronal excitability 3 88.36 High High
Disease Link Frequency Relevance Heat
Depression 442 100.00 Very High Very High Very High
Targeted Disruption 202 100.00 Very High Very High Very High
Anxiety Disorder 28 50.00 Quite Low
Neuropathic Pain 18 50.00 Quite Low
Nociception 18 46.12 Quite Low
Congenital Anomalies 5 42.40 Quite Low
Injury 29 32.32 Quite Low
Shock 7 19.88 Low Low
Pain 33 18.68 Low Low
Sprains And Strains 5 8.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The average pause duration decreased from 82 ± 22 ms to 43 ± 9 ms after LTD induction, corresponding to a 65% ± 14% reduction (n = 6; Figure 4C).
Negative_regulation (decreased) of Positive_regulation (induction) of LTD associated with depression
1) Confidence 0.05 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.45 Pain Relevance 0.22
In contrast, the induction of HFS-LTD is reduced in the SDH of GluR2 mutants.
Negative_regulation (reduced) of Positive_regulation (induction) of HFS-LTD associated with depression
2) Confidence 0.04 Published 2008 Journal Pain Section Abstract Doc Link 17826911 Disease Relevance 0.32 Pain Relevance 0.67
In vitro, we found a shortening of pauses when decreasing the number of active PFs or after inducing LTD.
Negative_regulation (decreasing) of Positive_regulation (inducing) of LTD associated with depression
3) Confidence 0.04 Published 2007 Journal Neuron Section Abstract Doc Link PMC1885969 Disease Relevance 0.42 Pain Relevance 0.21
In vitro, we found a shortening of pauses when decreasing the number of active PFs or after inducing LTD.
Negative_regulation (number) of Positive_regulation (inducing) of LTD associated with depression
4) Confidence 0.04 Published 2007 Journal Neuron Section Abstract Doc Link PMC1885969 Disease Relevance 0.42 Pain Relevance 0.21
The smaller reduction in the number of spikes in the burst after LTD induction we have observed (15% compared to 35% in their study) may be related to the different induction protocol or the more physiological temperatures used in our experiments.
Negative_regulation (reduction) of Positive_regulation (induction) of LTD in spikes associated with depression
5) Confidence 0.04 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.38 Pain Relevance 0.19
Next, we showed directly that LTD induction reduced postburst pause duration and that the first spike latency and the number of spikes in the burst are poorer candidates for pattern recognition compared to the pause.
Negative_regulation (reduced) of Positive_regulation (induction) of LTD in spike associated with depression
6) Confidence 0.04 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.31 Pain Relevance 0.15
2 (T site) impairs LTD induction at PF-PC synapses and caused CF territory expansion, but had little effect on PF-PC synapse formation and elimination of surplus CFs at proximal dendrites of PCs [21].
Negative_regulation (impairs) of Positive_regulation (induction) of LTD in dendrites associated with depression
7) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.28 Pain Relevance 0.70
A similar depression was also found in neurabin KO mice by LTD induction (80.3±1.9 % of baseline response, n?
Negative_regulation (found) of Positive_regulation (induction) of LTD associated with targeted disruption and depression
8) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.05 Pain Relevance 0.70
As shown in Figure 3B, we found that LTD induced by 1 Hz stimulation (15 min) was significantly reduced or completely abolished in transgenic mice (mean 84.4 ± 10.7%, n = 6 slices/6 mice; P < 0.01 as compared with LTD in wild-type mice).
Negative_regulation (reduced) of Positive_regulation (induced) of LTD associated with targeted disruption
9) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.52 Pain Relevance 0.42
As shown in Figure 3B, we found that LTD induced by 1 Hz stimulation (15 min) was significantly reduced or completely abolished in transgenic mice (mean 84.4 ± 10.7%, n = 6 slices/6 mice; P < 0.01 as compared with LTD in wild-type mice).
Negative_regulation (abolished) of Positive_regulation (induced) of LTD associated with targeted disruption
10) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.53 Pain Relevance 0.43
Accordingly, we found that chelation of postsynaptic Ca2+ (with 20 mM BAPTA intrapipette) completely prevented the induction of eCB-LTD at PrPFC synapses (Fig 5D), as in the nucleus accumbens synapses [28].
Negative_regulation (prevented) of Positive_regulation (induction) of eCB-LTD in synapses associated with nucleus accumbens and depression
11) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.71 Pain Relevance 0.53

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