INT146381

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 10
Disease Relevance 5.55
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptges) nucleus (Ptges) cytoplasm (Ptges)
Ptges (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 21 99.36 Very High Very High Very High
cytokine 8 92.28 High High
COX-2 inhibitor 9 91.20 High High
Inflammation 22 89.72 High High
Pain 13 85.44 High High
antagonist 16 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 136 99.76 Very High Very High Very High
Targeted Disruption 80 99.24 Very High Very High Very High
INFLAMMATION 32 99.16 Very High Very High Very High
Asthma 16 96.28 Very High Very High Very High
Disease 3 90.08 High High
Syndrome 9 89.76 High High
Aneurism 2 88.44 High High
Atherosclerosis 2 87.36 High High
Pain 12 85.44 High High
Myocardial Infarction 8 82.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, deletion of mPGES-1 permits rediversion of the PGH2 substrate to other PG synthases and augmented formation of PGI2 and PGD2 mitigates this effect.
Localization (deletion) of mPGES-1
1) Confidence 0.10 Published 2008 Journal J. Intern. Med. Section Abstract Doc Link 18410593 Disease Relevance 1.28 Pain Relevance 0.53
Our study investigated the cellular localization and distribution of COX-1, COX-2, mPGES-1, and mPGES-2 in organ tissues from a mouse model of human hypertension.
Spec (investigated) Localization (localization) of mPGES associated with hypertension
2) Confidence 0.06 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC1906712 Disease Relevance 0.55 Pain Relevance 0
Our study investigated the cellular localization and distribution of COX-1, COX-2, mPGES-1, and mPGES-2 in organ tissues from a mouse model of human hypertension.
Spec (investigated) Localization (localization) of mPGES associated with hypertension
3) Confidence 0.06 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC1906712 Disease Relevance 0.55 Pain Relevance 0
There are currently no published reports on the cellular expression and microanatomic location of COX-1, COX-2, mPGES-1, mPGES-2 in hypertensive transgenic mice.
Localization (location) of mPGES associated with targeted disruption and hypertension
4) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.94 Pain Relevance 0.09
There are currently no published reports on the cellular expression and microanatomic location of COX-1, COX-2, mPGES-1, mPGES-2 in hypertensive transgenic mice.
Localization (location) of mPGES associated with targeted disruption and hypertension
5) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.93 Pain Relevance 0.09
Our work suggests that in hypertensive mice, there are (a) significant microanatomic variations in the pulmonary, renal, and cardiac distribution and cellular localization of COX-1, COX-2, mPGES-1, and mPGES-2, and (b) no differences in expression between genders.


1.

Localization (localization) of mPGES associated with hypertension
6) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC1906712 Disease Relevance 0.17 Pain Relevance 0
cardiac distribution and cellular localization of mPGES-1, mPGES-2,
Localization (localization) of mPGES
7) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.30 Pain Relevance 0.05
Our work suggests that in hypertensive mice, there are (a) significant microanatomic variations in the pulmonary, renal, and cardiac distribution and cellular localization of COX-1, COX-2, mPGES-1, and mPGES-2, and (b) no differences in expression between genders.


1.

Localization (localization) of mPGES associated with hypertension
8) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC1906712 Disease Relevance 0.17 Pain Relevance 0
cardiac distribution and cellular localization of mPGES-1, mPGES-2,
Localization (localization) of mPGES
9) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.30 Pain Relevance 0.05
Could the targeting of microsomal prostaglandin E(2) synthase (mPGES-1) lead to novel anti-inflammatory drugs with possibly reduced risks of gastrointestinal and cardiovascular side effects?
Localization (targeting) of mPGES-1 associated with inflammation and cinod
10) Confidence 0.00 Published 2007 Journal Mol. Interv. Section Abstract Doc Link 17827439 Disease Relevance 0.36 Pain Relevance 0.45

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