INT146400

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.91
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DNMT1) DNA binding (DNMT1) transcription factor binding (DNMT1)
DNMT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 100.00 Very High Very High Very High
aspirin 1 100.00 Very High Very High Very High
dexamethasone 92 96.96 Very High Very High Very High
COX2 1 25.00 Low Low
Bioavailability 6 22.08 Low Low
cytokine 2 10.48 Low Low
withdrawal 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 100.00 Very High Very High Very High
Chronic Hepatitis 3 100.00 Very High Very High Very High
Hepatocellular Cancer 1 98.92 Very High Very High Very High
Hepatitis C Virus Infection 2 90.16 High High
Infection 7 89.76 High High
Cancer 49 71.12 Quite High
Toxicity 13 64.08 Quite High
Solid Tumor 8 58.16 Quite High
Myelodysplastic Syndromes 58 50.00 Quite Low
Disease 67 29.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND AND AIM: Cyclooxygenase-2 (COX-2), a target of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), is upregulated in chronic hepatitis B and may have a role in hepatocellular carcinoma.
Positive_regulation (upregulated) of AIM associated with aspirin, chronic hepatitis, inflammation, hepatocellular cancer and cinod
1) Confidence 0.45 Published 2007 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 17845691 Disease Relevance 0.65 Pain Relevance 0.25
This combination will offer new options to increase the DNMT inhibitor activity in patients.
Positive_regulation (increase) of DNMT
2) Confidence 0.29 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.26 Pain Relevance 0
Confluent monolayers of hMSCs in 6 well plates (10 cm2 per well) were incubated in adipoinductive medium (AIM) consisting of CCM containing 0.5 ?
Positive_regulation (incubated) of AIM
3) Confidence 0.04 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.09
Confluent monolayers of hMSCs in 6 well plates (10 cm2 per well) were incubated in adipoinductive medium (AIM) consisting of CCM containing 0.5 ?
Positive_regulation (adipoinductive) of AIM
4) Confidence 0.04 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.09

General Comments

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