INT146402

Context Info Confidence 0.31 First Reported 2006 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 6 Total Number 8 Disease Relevance 1.52 Pain Relevance 0.44

signal transduction (Gnat3) GTPase activity (Gnat3) cytoplasm (Gnat3) signal transducer activity (Gnat3)

Anatomy Link Frequency CAF 1 ducts 1 sublingual 1 Gnat3 (Mus musculus)

Pain Link Frequency Relevance Heat transdermal 16 100.00 addiction 10 100.00 tolerance 77 77.68 Potency 11 65.76 Angina 5 57.52 Bile 22 50.00 Piles 2 50.00 Inflammation 3 47.84 Bioavailability 9 27.48 headache 15 10.00

Disease Link Frequency Relevance Heat Stress 17 99.92 Pancreatitis 140 99.20 Coronary Artery Disease 4 59.68 Increased Venous Pressure Under Development 8 58.64 Angina 2 57.52 Cv General 3 Under Development 3 55.76 Anorectal Disorders 2 52.52 INFLAMMATION 3 47.84 Pressure Volume 2 Under Development 16 5.00 Headache 14 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present study we could demonstrate that bilirubin efficiently decreases mitochondrial oxidative stress in response to GTN treatment (Figure 2C).

Regulation (response) of GTN associated with stress

1) Confidence 0.31 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.10 Pain Relevance 0.07

And so if we put the two results together, we could easily conclude that the way of sublingual GTN is more effective than the way of transdermal GTN for preventing the PEP, although the later enrolled far more patients (sublingual GTN 260 VS transdermal GTN 1266).

Regulation (effective) of GTN in sublingual associated with transdermal and pancreatitis

2) Confidence 0.28 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2921391 Disease Relevance 0.73 Pain Relevance 0.18

The inclusive criteria were: (1) studies that examine the effect of GTN on the incidence of PEP and/or on the cannulation of ducts; (2) studies that were prospective, randomized and placebo controlled; (3) studies in humans; (4) date not duplicated in another manuscript; (5) the age of patient population should be over 18 years; (6) the patients were scheduled to undergo ERCP; (7) co-interventions (including treatment of complications) were allowed if administered equally to all intervention groups.

Spec (examine) Regulation (effect) of GTN in ducts associated with pancreatitis

3) Confidence 0.28 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2921391 Disease Relevance 0.36 Pain Relevance 0

Accordingly, partitioning between reversible and irreversible inhibition in the absence of a reductant will depend on the ratio of the rates of disulfide formation (krev) and irreversible inactivation (kirr·[GTN]), the latter of which depends on the GTN concentration.

Regulation (depends) of GTN

4) Confidence 0.19 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0

Because the active site thiol of ALDH2 is oxidized in the process, it must be regenerated by suitable reductants, which might explain the dependence of GTN bioconversion on the presence of thiols.

Spec (might) Regulation (dependence) of GTN associated with addiction

5) Confidence 0.19 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0.16 Pain Relevance 0.13

CONCLUSION: Both DTZ and GTN are equally effective and can be used for the management of CAF.

Regulation (effective) of GTN in CAF

6) Confidence 0.12 Published 2008 Journal Int J Colorectal Dis Section Body Doc Link 17846781 Disease Relevance 0.05 Pain Relevance 0

The effect of the E487K substitution on GTN reductase activity decreased with increasing GTN concentration (3 and 15% of wild type with 2 and 100 ?

Regulation (effect) of GTN

7) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0

The present results showing that the Asian variant catalyzes significant bioactivation of GTN despite very low denitration activity may at least partially explain the GTN response in these subjects.

Regulation (response) of GTN

8) Confidence 0.06 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0.12 Pain Relevance 0.06

General Comments

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