INT146412

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 5.22
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tnf, Trpv1) transport (Trpv1) intracellular (Tnf)
extracellular matrix organization (Tnf) transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
nociceptor 4
DRG 2
Tnf (Mus musculus)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 16 100.00 Very High Very High Very High
primary afferent fibers 2 99.80 Very High Very High Very High
dorsal root ganglion 12 98.82 Very High Very High Very High
qutenza 4 98.64 Very High Very High Very High
Hyperalgesia 14 97.32 Very High Very High Very High
Etanercept 2 94.92 High High
Kinase C 2 94.64 High High
Thermal hyperalgesia 2 94.56 High High
antagonist 2 94.48 High High
Inflammation 2 86.36 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 12 98.82 Very High Very High Very High
Nociception 4 98.72 Very High Very High Very High
Hyperalgesia 16 97.32 Very High Very High Very High
Necrosis 6 93.08 High High
Cancer 18 92.72 High High
Targeted Disruption 2 86.76 High High
INFLAMMATION 2 86.36 High High
Neuropathic Pain 2 85.68 High High
Metastasis 2 83.72 Quite High
Pain 2 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we investigated in cultured dorsal root ganglion (DRG) neurones, the somata of primary afferent fibres, whether TNFalpha increases TRPV1 receptor expression.
TNFalpha Spec (whether) Positive_regulation (increases) of Gene_expression (expression) of TRPV1 in DRG associated with ganglion cysts, dorsal root ganglion and primary afferent fibers
1) Confidence 0.66 Published 2007 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 17851089 Disease Relevance 0.99 Pain Relevance 0.58
Furthermore, we found that activation of ERK but not of p38 kinase or cyclooxygenases is critically involved in the TNFalpha-induced increase of TRPV1 receptor expression.
TNFalpha Positive_regulation (increase) of Gene_expression (expression) of TRPV1
2) Confidence 0.66 Published 2007 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 17851089 Disease Relevance 0.85 Pain Relevance 0.50
TNFalpha enhanced the expression of the nociceptor-specific heat transducer ion channel transient receptor potential vanilloid 1 (TRPV1) and increased the amplitudes of capsaicin and heat-activated ionic currents via p38/MAP (mitogen-activated protein) kinase and PKC (protein kinase C).
TNFalpha Positive_regulation (enhanced) of Gene_expression (expression) of transient receptor potential vanilloid 1 in nociceptor associated with kinase c, qutenza and nociceptor
3) Confidence 0.66 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463260 Disease Relevance 1.69 Pain Relevance 1.07
TNFalpha enhanced the expression of the nociceptor-specific heat transducer ion channel transient receptor potential vanilloid 1 (TRPV1) and increased the amplitudes of capsaicin and heat-activated ionic currents via p38/MAP (mitogen-activated protein) kinase and PKC (protein kinase C).
TNFalpha Positive_regulation (enhanced) of Gene_expression (expression) of TRPV1 in nociceptor associated with kinase c, qutenza and nociceptor
4) Confidence 0.47 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463260 Disease Relevance 1.69 Pain Relevance 1.07

General Comments

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