INT146421

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.94
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch3) plasma membrane (Notch3) nucleus (Notch3)
Anatomy Link Frequency
cleavage 1
Notch3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 3 93.64 High High
Thalamus 1 47.60 Quite Low
imagery 1 41.76 Quite Low
cva 1 32.40 Quite Low
Disease Link Frequency Relevance Heat
Cadasil 12 99.98 Very High Very High Very High
Leukoencephalopathies 2 97.04 Very High Very High Very High
Headache 3 93.64 High High
Stroke 2 92.84 High High
Dementia 3 91.84 High High
Convulsion 1 89.44 High High
Learning Disorders 1 88.48 High High
Syndrome 1 85.20 High High
Pseudobulbar Palsy 2 80.52 Quite High
Intellectual Impairment 1 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[A new Spanish family with CADASIL associated with 346C>T mutation of NOTCH3 gene].
NOTCH3 gene Binding (associated) of associated with cadasil
1) Confidence 0.35 Published 2007 Journal Neurologia Section Title Doc Link 17853970 Disease Relevance 1.12 Pain Relevance 0.09
On binding to its ligand, Notch3 normally undergoes proteolytic cleavage, resulting in the clearance of the extracellular domain.
Notch3 Binding (binding) of in cleavage
2) Confidence 0.21 Published 2008 Journal Brain Nerve Section Abstract Doc Link 19069156 Disease Relevance 0.82 Pain Relevance 0.07

General Comments

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