INT14647

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 4.69
Pain Relevance 14.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)
Anatomy Link Frequency
spines 2
dorsal root 1
ACC 1
synapses 1
cortex 1
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 592 100.00 Very High Very High Very High
nMDA receptor 383 100.00 Very High Very High Very High
Analgesic 9 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
depression 16 99.96 Very High Very High Very High
Anterior cingulate cortex 412 99.56 Very High Very High Very High
antagonist 57 99.34 Very High Very High Very High
excitatory amino acid 3 98.96 Very High Very High Very High
Glutamate 53 98.72 Very High Very High Very High
Delta opioid receptors 2 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 16 99.96 Very High Very High Very High
Nociception 30 99.56 Very High Very High Very High
Pain 103 98.08 Very High Very High Very High
Injury 35 94.84 High High
Targeted Disruption 93 91.80 High High
Disseminated Intravascular Coagulation 42 91.24 High High
Urological Neuroanatomy 80 89.16 High High
INFLAMMATION 51 85.04 High High
Neuroblastoma 1 83.60 Quite High
Glioma 1 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that long duration of the dorsal root-evoked contralateral ventral root potential is a consequence of the activation of the N-methyl-D-aspartate receptor operated ion channels by excitatory amino acid transmitters.
Positive_regulation (activation) of N-methyl-D-aspartate receptor in dorsal root associated with nmda receptor and excitatory amino acid
1) Confidence 0.67 Published 1990 Journal Neuroscience Section Abstract Doc Link 1700328 Disease Relevance 0 Pain Relevance 0.94
Previous in situ hybridization experiments have suggested that NR2A and NR2B but not NR1 mRNA may be upregulated in both young and adult PrP-null mice (Maglio et al., 2004, 2006), which is not supported by our semiquantitative PCR experiments.
Positive_regulation (upregulated) of NR2A
2) Confidence 0.49 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.05 Pain Relevance 0.06
For example, dark rearing from birth attenuates the developmental increase in NR2A in the visual cortex [24,25].
Positive_regulation (increase) of NR2A in cortex
3) Confidence 0.47 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.30
Using these antagonists, recent studies have shown that NR2A-containg NMDARs are required for LTP, whereas NR2B NMDARs are required for LTD [11,12].
Positive_regulation (required) of NR2A-containg associated with antagonist
4) Confidence 0.47 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.29 Pain Relevance 0.45
Our recent results indicate that both NR2A and NR2B are required for the induction of cingulate LTP and LTD [17,18].
Positive_regulation (required) of NR2A
5) Confidence 0.47 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.21 Pain Relevance 0.49
In primary striatal cultures, NT-3 treatment induced an enhancement in NR2A, but not NR2B, protein levels.
Positive_regulation (enhancement) of NR2A
6) Confidence 0.44 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.06 Pain Relevance 0.24
Subsequently, NMDA receptors including NR2A and NR2B can be activated, resulting in the elevation of intracellular Ca2+ in postsynaptic cells [4].
Positive_regulation (activated) of NR2A associated with nmda receptor
7) Confidence 0.43 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.19 Pain Relevance 0.69
The activation of NMDA receptors including NR2A and NR2B subunits and L-type voltage-gated calcium channels (L-VDCCs) causes an increase in postsynaptic calcium in dendritic spines [11,13].
Positive_regulation (activation) of NR2A in spines associated with calcium channel and nmda receptor
8) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.31 Pain Relevance 0.99
The deficit of endogenous NT-3 induced a decrease in NR1 and NR2A subunits at postnatal day (P) 0 and P3 mice respectively, whereas an upregulation was observed in 12 week old NT-3 +/- mice.
Positive_regulation (upregulation) of NR2A
9) Confidence 0.41 Published 2007 Journal Neuroscience Section Abstract Doc Link 17081696 Disease Relevance 0.07 Pain Relevance 0.26
The activation of NMDA receptors including NR2A and NR2B subunits and L-type voltage-gated calcium channels (L-VDCCs) induces an increase in postsynaptic calcium in dendritic spines [3,9].
Positive_regulation (activation) of NR2A in spines associated with calcium channel and nmda receptor
10) Confidence 0.38 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0.15 Pain Relevance 0.79
The formation of functional NMDA receptors requires a combination of NR1 and at least one NR2 subunit [2].
Positive_regulation (requires) of NR2 associated with nmda receptor
11) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694782 Disease Relevance 0 Pain Relevance 0.57
In its role in targeting NR2A-NMDARs to the synapse, Neto1 may be comparable to the TARPs, which control targeting of AMPARs to synapses [44,45].
Positive_regulation (targeting) of NR2A in synapses
12) Confidence 0.37 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.03
The immunolabeled NR1, NR2A and NR2B subunits were increased by approximately 123%, 62% and 100% (Figure 2D) respectively; in the membrane fractions isolated from the retinae of the rdta mice.


Positive_regulation (increased) of NR2A
13) Confidence 0.36 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.05
These results suggest that N/OFQ stimulated nNOS activity by a biochemical cascade initiated by activation of NMDA receptors containing NR2A.
Positive_regulation (activation) of NR2A associated with nmda receptor
14) Confidence 0.34 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17350656 Disease Relevance 0.05 Pain Relevance 0.51
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Positive_regulation (activation) of N-methyl-D-aspartate receptor associated with nociception, nociceptor and nmda receptor
15) Confidence 0.32 Published 2007 Journal J. Pharmacol. Sci. Section Title Doc Link 17452810 Disease Relevance 0.24 Pain Relevance 0.96
Therefore, an increased NR2A/NR2B ratio is likely to result in a higher threshold for LTP induction, which could explain the reduction of PTP and LTP.
Positive_regulation (increased) of NR2A associated with long-term potentiation
16) Confidence 0.31 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0.15 Pain Relevance 0.62
Glutamate N-methyl D-aspartate (NMDA) receptors in the ACC are critical for the induction of LTP, including both NR2A and NR2B subunits.
Positive_regulation (induction) of NR2A in ACC associated with glutamate, long-term potentiation and anterior cingulate cortex
17) Confidence 0.28 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2734546 Disease Relevance 0.32 Pain Relevance 0.87
For example, both N-methyl-D-aspartate (NMDA) receptor subunit 2A and 2B (NR2A and NR2B) contribute to cingulate LTP [3], while NR2A is preferentially contributing to hippocampal LTP [11,12].
Positive_regulation (contributing) of NR2A associated with long-term potentiation
18) Confidence 0.26 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0.08 Pain Relevance 0.73
The observed reduction of NR2B subunits results in an increased NR2A/NR2B ratio.
Positive_regulation (increased) of NR2A
19) Confidence 0.22 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0.17 Pain Relevance 0.56
The formation of functional NMDARs requires a combination of NR1, an essential channel-forming subunit, and at least one NR2 subunit.
Positive_regulation (requires) of NR2
20) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.36 Pain Relevance 1.23

General Comments

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