INT146479

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.85
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (HAS1) cell adhesion (HAS1)
Anatomy Link Frequency
lining cells 4
TMJ 2
skin 2
HAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 9 96.88 Very High Very High Very High
rheumatoid arthritis 39 89.32 High High
Osteoarthritis 65 89.04 High High
cytokine 3 71.20 Quite High
Inflammation 13 69.88 Quite High
Pain 19 5.00 Very Low Very Low Very Low
Botox 4 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 9 96.88 Very High Very High Very High
Rheumatoid Arthritis 39 89.32 High High
Osteoarthritis 73 89.04 High High
Necrosis 2 72.68 Quite High
Cancer 2 72.32 Quite High
INFLAMMATION 14 69.88 Quite High
Wrinkles 13 66.72 Quite High
Pigment Disorder 1 65.76 Quite High
Aging 19 43.24 Quite Low
Cicatrix 6 42.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, direct up-regulation of HAS gene expression does not seem to be the explanation for the increased amount of HA in the medium in our experiments.
Regulation (regulation) of Gene_expression (expression) of HAS
1) Confidence 0.45 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.40 Pain Relevance 0.16
Addition of GlcN-HCl or Gluc did not alter HAS gene expression significantly.
Neg (not) Regulation (alter) of Gene_expression (expression) of HAS
2) Confidence 0.45 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.41 Pain Relevance 0.17
In the present study, we investigated the regulatory roles of IL-1beta on HAS gene expression and HA production by the fibroblastic synovial lining cells.
Spec (investigated) Regulation (roles) of Gene_expression (expression) of HAS gene in lining cells
3) Confidence 0.44 Published 2008 Journal Arch. Oral Biol. Section Abstract Doc Link 17868639 Disease Relevance 0.18 Pain Relevance 0.18
Regulation of HAS expression in human synovial lining cells of TMJ by IL-1beta.
Regulation (Regulation) of Gene_expression (expression) of HAS in lining cells
4) Confidence 0.27 Published 2008 Journal Arch. Oral Biol. Section Title Doc Link 17868639 Disease Relevance 0.17 Pain Relevance 0.22
From these results, it is concluded that IL-1beta functions on regulating HAS expression and consequently promoting the secretion of HA in synovial lining cells from TMJ.
Regulation (regulating) of Gene_expression (expression) of HAS in TMJ associated with snapping jaw
5) Confidence 0.23 Published 2008 Journal Arch. Oral Biol. Section Abstract Doc Link 17868639 Disease Relevance 0.24 Pain Relevance 0.24
It has been suggested that the expression level of HAS proteins and their synthetic activities regulate the total volume of hyaluronan produced by cells, because detergent-purified HAS proteins alone can synthesize hyaluronan and no associated proteins or components are necessary for hyaluronan synthesis in vitro [41].
Regulation (regulate) of Gene_expression (expression) of HAS
6) Confidence 0.21 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064865 Disease Relevance 0.33 Pain Relevance 0.16
A lipophilized ester-derivative of salicylic acid, capryloyl salicylic acid (CSA), has been shown to be an effective exfoliating agent due to its reduced penetration in the skin.34
Regulation (derivative) of Gene_expression (shown) of has in skin
7) Confidence 0.07 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946856 Disease Relevance 0.13 Pain Relevance 0

General Comments

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