INT146481

Context Info Confidence 0.61 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.08 Pain Relevance 0.61

Anatomy Link Frequency synovial cells 2 HAS2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 2 80.08 Osteoarthritis 28 79.32 Snapping jaw 3 79.28 Inflammation 6 78.76 Pain 16 5.00 metalloproteinase 2 5.00 Analgesic 2 5.00

Disease Link Frequency Relevance Heat Necrosis 2 81.56 Cancer 2 81.20 Osteoarthritis 36 79.32 Temporomandibular Joint Syndrome 3 79.28 INFLAMMATION 6 78.76 Pain 16 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recklies et al. observed that the HAS1 message levels were always more abundant than that for HAS2 in synovial cells, and that the HAS3 message levels were always least abundant.

Gene_expression (abundant) of HAS2 in synovial cells

1) Confidence 0.61 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.46 Pain Relevance 0.19

Recklies et al. observed that the HAS1 message levels were always more abundant than that for HAS2 in synovial cells, and that the HAS3 message levels were always least abundant.

Gene_expression (message) of HAS2 in synovial cells

2) Confidence 0.61 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.46 Pain Relevance 0.19

The expression of HAS2 and 3 mRNA were enhanced about 4.2- and 7.2-fold after 4h stimulation with 1ng/ml of IL-1beta, respectively.

Gene_expression (expression) of HAS2

3) Confidence 0.52 Published 2008 Journal Arch. Oral Biol. Section Abstract Doc Link 17868639 Disease Relevance 0.16 Pain Relevance 0.24

General Comments

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