INT146488

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 4.63
Pain Relevance 5.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a2) plasma membrane (Slc12a2) transmembrane transport (Slc12a2)
Anatomy Link Frequency
neurons 3
finger 1
dorsal root ganglia 1
respiratory 1
Slc12a2 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 21 99.84 Very High Very High Very High
allodynia 240 99.32 Very High Very High Very High
GABAergic 61 98.66 Very High Very High Very High
gABA 217 98.44 Very High Very High Very High
Dorsal horn 21 98.32 Very High Very High Very High
c fibre 9 98.08 Very High Very High Very High
Inflammation 39 93.48 High High
Thermal hyperalgesia 3 89.36 High High
qutenza 96 89.20 High High
fibrosis 4 87.92 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 57 100.00 Very High Very High Very High
Ganglion Cysts 26 99.84 Very High Very High Very High
Neuropathic Pain 248 99.32 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 8 95.84 Very High Very High Very High
Peripheral Arterial Disease 12 93.84 High High
INFLAMMATION 45 93.48 High High
Hyperalgesia 52 89.36 High High
Cystic Fibrosis 4 88.48 High High
Fungal Infection 12 82.16 Quite High
Infection 30 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry showed that a major fraction of neurons in the dorsal root ganglia express the cation-chloride co-transporters NKCC1 and KCC2, indicating that the molecular equipment for Cl(-) accumulation and extrusion is present.
Gene_expression (express) of NKCC1 in dorsal root ganglia
1) Confidence 0.73 Published 2007 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 17869474 Disease Relevance 0.22 Pain Relevance 0.31
The majority of these neurons also express NKCC1 [29], hence, we reasoned that spinal TRPV1 receptors might be involved in regulating NKCC1 activity.
Gene_expression (express) of NKCC1 in neurons
2) Confidence 0.72 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 1.08 Pain Relevance 1.37
The molecular mechanism for depolarizing GABAAR currents appears to be expression of NKCC1 in DRG neurons leading to a high intracellular Cl- concentration and Cl- efflux through the GABAAR channel upon pharmacological stimulation [2,3].
Gene_expression (expression) of NKCC1 in neurons associated with dorsal root ganglion
3) Confidence 0.72 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.84 Pain Relevance 1.30
Next, we tested for the expression of NKCC1 in coronal VNO slices by immunocytochemistry.
Gene_expression (expression) of NKCC1
4) Confidence 0.64 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2806418 Disease Relevance 0 Pain Relevance 0.08
We and others have proposed that GABAergic mechanisms may explain allodynia in inflamed conditions such that NKCC1 activity increases leading to a large depolarization in C-fibers, causing spiking, in response to A?
Gene_expression (activity) of NKCC1 associated with c fibre, allodynia and gabaergic
5) Confidence 0.62 Published 2007 Journal Mol Pain Section Body Doc Link PMC1929059 Disease Relevance 0.90 Pain Relevance 1.32
Fourth, NKCC1, a Cl?
Gene_expression (Fourth) of NKCC1
6) Confidence 0.55 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2806418 Disease Relevance 0 Pain Relevance 0
o during stimulation (compared to [9],[13] whereas mc3 and mc5 associated with H3 and H5 (NBC only and NBC+NKCC1, respectively) predict an increase in [Cl?]
Gene_expression (respectively) of NKCC1
7) Confidence 0.34 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
The NKCC1 cotransporter responds to relative changes in ion concentrations (see Methods), and as [Na+]o and [Cl?]
Gene_expression (cotransporter) of NKCC1
8) Confidence 0.34 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
The model underlying H4 (mc4, only NKCC1) predicts a small decrease in [Cl?]
Gene_expression (only) of NKCC1
9) Confidence 0.34 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
The model underlying H4 (mc4, only NKCC1) predicts a small decrease in [Cl?]
Gene_expression (The) of NKCC1
10) Confidence 0.34 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
If we require that our models produce ion concentrations in the excited state that are consistent with empirically observed levels within the narrow time window relevant for the experimental ECS shrinkage observations, the presence of either NBC or NKCC1 or both seems necessary in order to produce ECS shrinkage to the extent reported in the literature.
Gene_expression (presence) of NKCC1
11) Confidence 0.30 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0
Early in development the expression of the NKCC1 transporter, which is driven by sodium and potassium gradients, leads to the accumulation of high chloride concentrations inside the young neuron.
Gene_expression (expression) of NKCC1 in neuron
12) Confidence 0.22 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.14 Pain Relevance 0.20
-cotransporter (NKCC1) which sets up a Cl?
Gene_expression (cotransporter) of NKCC1
13) Confidence 0.14 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2927192 Disease Relevance 0 Pain Relevance 0.38
Interestingly, NKCC-1 gene knockout does not result in respiratory defects in mice [6].
Gene_expression (knockout) of NKCC-1 gene in respiratory associated with targeted disruption
14) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994757 Disease Relevance 0.50 Pain Relevance 0.08
cotransporter (NKCC), which mediates Cl?
Gene_expression (cotransporter) of NKCC
15) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994757 Disease Relevance 0.40 Pain Relevance 0.07
Interestingly, the major transporters involved in azole resistance (CgCDR1, CgCDR2, and CgSNQ2) were not always coordinately expressed in presence of specific CgPDR1 GOF mutations, thus suggesting that these are rather trans-acting elements (GOF in CgPDR1) than cis-acting elements (promoters) that lead to azole resistance by upregulating specific combinations of ABC-transporter genes.
Neg (not) Gene_expression (expressed) of transporters
16) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2607542 Disease Relevance 0.17 Pain Relevance 0
In C. glabrata, the expression of ABC transporters is mediated by a zinc finger transcription factor called CgPDR1.
Gene_expression (expression) of transporters in finger
17) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2607542 Disease Relevance 0.37 Pain Relevance 0

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