INT146504

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.58
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) signal transduction (Ccr2) plasma membrane (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
monocytes 1
THP-1 1
microglia 1
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 22 99.64 Very High Very High Very High
antagonist 10 99.64 Very High Very High Very High
Inflammation 98 99.08 Very High Very High Very High
Demyelination 12 98.56 Very High Very High Very High
Spinal cord 30 98.28 Very High Very High Very High
Neuropathic pain 61 97.60 Very High Very High Very High
chemokine 114 95.92 Very High Very High Very High
cytokine 12 93.00 High High
agonist 15 80.48 Quite High
Dynorphin 1 76.68 Quite High
Disease Link Frequency Relevance Heat
Pain 29 99.64 Very High Very High Very High
INFLAMMATION 104 99.08 Very High Very High Very High
Nervous System Injury 32 98.92 Very High Very High Very High
Demyelinating Disease 78 98.56 Very High Very High Very High
Spinal Cord Injury 5 98.28 Very High Very High Very High
Neuropathic Pain 70 97.60 Very High Very High Very High
Disease 48 97.16 Very High Very High Very High
Targeted Disruption 37 96.12 Very High Very High Very High
Multiple Sclerosis 169 93.28 High High
Injury 11 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, CCR2 antagonists [39] will likely affect CCR2+ infiltrating monocytes but not resident CX3CR1+ microglia.
Neg (not) Regulation (affect) of CCR2 in microglia associated with antagonist
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.41 Pain Relevance 0.09
We now know that many receptors such as P2X4, CX3CR1, and CCR2 are specifically expressed or up regulated in spinal microglia after nerve injury or spinal cord injury, which is essential for neuropathic pain development and maintenance.
Regulation (regulated) of CCR2 associated with nervous system injury, neuropathic pain and spinal cord
2) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 0.83 Pain Relevance 0.76
In Ly6Chi monocytes, permeabilization increased the CCR2 signal twofold, indicating that approximately 50% of total CCR2 was cytoplasmic, but had little effect on CCR2 staining in Ly6Clo monocytes.
Neg (little) Regulation (effect) of CCR2 in monocytes
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.27 Pain Relevance 0.06
Taken together with data from CCR2-deficient mice, these present data confirm a key role of CCL2/CCR2 axis in pain pathways and suggest that inhibiting this axis may result in novel pain therapies.
Regulation (role) of CCR2 associated with pain
4) Confidence 0.19 Published 2007 Journal Neuroscience Section Abstract Doc Link 17870246 Disease Relevance 0.84 Pain Relevance 0.78
These studies underscore the importance of CCR1 and CCR2 in the development of inflammatory demyelination and give support to novel alternative strategies targeting these CCR molecules.
Regulation (importance) of CCR2 associated with demyelination and inflammation
5) Confidence 0.18 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.16 Pain Relevance 0.28
Stimulation of THP-1 cells with CCL2 resulted in a time-dependent down regulation of CCR2 (Figure 4A).
Regulation (regulation) of CCR2 in THP-1
6) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855346 Disease Relevance 0.07 Pain Relevance 0.23

General Comments

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