INT146505

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.98
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
retina 2
brain 2
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 96.80 Very High Very High Very High
chemokine 4 93.56 High High
glial activation 1 83.16 Quite High
allodynia 1 78.00 Quite High
Sciatic nerve 2 76.00 Quite High
IPN 1 61.84 Quite High
Glutamate 28 61.80 Quite High
Multiple sclerosis 3 61.52 Quite High
rheumatoid arthritis 1 58.52 Quite High
imagery 3 57.44 Quite High
Disease Link Frequency Relevance Heat
Glaucoma 39 99.60 Very High Very High Very High
Nociception 4 99.52 Very High Very High Very High
Death 15 99.12 Very High Very High Very High
Stab Wounds 15 98.68 Very High Very High Very High
Pain 3 96.80 Very High Very High Very High
Ocular Hypertension 8 96.08 Very High Very High Very High
Injury 60 95.20 Very High Very High Very High
Hypertrophy 3 89.76 High High
Neuropathic Pain 1 78.00 Quite High
Inflammatory Pain 1 61.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in glial fibrillary acid protein (GFAP) immunoreactivity was observed in the contralateral SC at 7, 30, and 90 days after NMDA injection and in the ipsilateral SC at 7 days, while brain-derived neurotrophic factor (BDNF) expression was increased in the contralateral SC at 30 and 90 days.
Positive_regulation (increase) of Regulation (immunoreactivity) of GFAP in brain
1) Confidence 0.44 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2664844 Disease Relevance 0 Pain Relevance 0
GFAP immunoreactivity was increased in Müller cells from the inner to the outer limiting membranes in retina from rats with elevated intraocular pressure [37].
Positive_regulation (increased) of Regulation (immunoreactivity) of GFAP in retina associated with ocular hypertension
2) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.99 Pain Relevance 0.16
At 3 days post lesion, GFAP immunoreactivity was increased in both WT and null mice, but the response was markedly abrogated in IL-1R1-null mice.
Positive_regulation (increased) of Regulation (immunoreactivity) of GFAP
3) Confidence 0.39 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.28 Pain Relevance 0.09
In the present study, we assess nociceptive responses of mice that overexpressed CCL2 under control of glial fibrillary acidic protein promoter (CCL2 tg).
Positive_regulation (overexpressed) of Regulation (control) of fibrillary acidic protein promoter associated with nociception
4) Confidence 0.14 Published 2007 Journal Neuroscience Section Abstract Doc Link 17870246 Disease Relevance 0.70 Pain Relevance 0.46

General Comments

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