INT146545

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 18.87
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (MSH2) ATPase activity (MSH2) nucleus (MSH2)
enzyme binding (MSH2) DNA binding (MSH2)
Anatomy Link Frequency
skin 4
MLH1 4
rectum 3
urinary bladder 2
epithelium 2
MSH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 92.12 High High
Piles 3 75.00 Quite High
Pain 10 67.16 Quite High
cytokine 12 59.84 Quite High
Inflammation 73 59.08 Quite High
palliative 13 5.00 Very Low Very Low Very Low
endometriosis 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 322 99.96 Very High Very High Very High
Skin Cancer 64 99.88 Very High Very High Very High
Endometroid Carcinoma 12 99.68 Very High Very High Very High
Oral Lichen Planus 210 99.52 Very High Very High Very High
Microsatellite Instability 233 98.96 Very High Very High Very High
Myeloid Leukemia 24 98.72 Very High Very High Very High
Breast Cancer 57 98.34 Very High Very High Very High
Adenoma 24 97.08 Very High Very High Very High
Hyperplasia 21 96.84 Very High Very High Very High
Colon Cancer 131 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the reduced expression of hMSH2 protein could make the epithelium of OLP more susceptible to DNA mutation, making it prone to oral squamous cell carcinoma development.
Negative_regulation (reduced) of Gene_expression (expression) of hMSH2 in epithelium associated with oral lichen planus and skin cancer
1) Confidence 0.56 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.21 Pain Relevance 0
With regard to sporadic forms of tumors, reduced expression of hMSH2 have been reported in a distinct subset of oral and neck squamous cell 16, colorectal 17, endometrial 18, ovarian 19 and urinary bladder carcinomas 20.
Negative_regulation (reduced) of Gene_expression (expression) of hMSH2 in urinary bladder associated with cancer and bladder cancer
2) Confidence 0.56 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 0.84 Pain Relevance 0.09
In the present study, we demonstrated decreased expression of hMSH2 protein in reticular and atrophic/erosive OLP compared to oral normal mucosa.
Negative_regulation (decreased) of Gene_expression (expression) of hMSH2 associated with oral lichen planus
3) Confidence 0.56 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.34 Pain Relevance 0.03
These preliminary data suggest that lower MSH2 expression in the normal colonic mucosa, at least in the ascending colon and rectum, may be associated with increased risk of incident, sporadic colorectal adenoma as well as with modifiable risk factors for colorectal neoplasms, thus supporting further investigation of MSH2 expression as a potential modifiable biomarker of risk for colorectal neoplasms.
Negative_regulation (lower) of Gene_expression (expression) of MSH2 in rectum associated with colorectal cancer and adenoma
4) Confidence 0.43 Published 2009 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 19861524 Disease Relevance 0.85 Pain Relevance 0.09
The reduced expression of hMSH2 protein in oral lichen planus suggests that this lesion is more susceptible to mutation and therefore facilitate the development of oral squamous cell carcinoma.


1.

Negative_regulation (reduced) of Gene_expression (expression) of hMSH2 associated with oral lichen planus and skin cancer
5) Confidence 0.41 Published 2004 Journal International Journal of Medical Sciences Section Abstract Doc Link PMC1074709 Disease Relevance 0.97 Pain Relevance 0.03
These tumors show high frequency of microsatellite instability and are immunohistochemically characterized by the lack of hMSH2 protein expression 15.
Negative_regulation (lack) of Gene_expression (expression) of hMSH2 associated with cancer and microsatellite instability
6) Confidence 0.41 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.46 Pain Relevance 0.06
Moreover, Lo Muzio et al. 29 reported that 5% of the cases of oral squamous cell carcinoma show diminished expression of hMSH2 protein.
Negative_regulation (diminished) of Gene_expression (expression) of hMSH2 associated with skin cancer
7) Confidence 0.41 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.44 Pain Relevance 0.03
Our study also found that As exposure has a profound negative impact on DNA repair, decreasing positive expression for XRCC1, MGMT, and hMSH2 mRNA with the increasing severity of skin lesion in arsenicosis patients (Table 3).
Negative_regulation (decreasing) of Gene_expression (expression) of hMSH2 in skin
8) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.12 Pain Relevance 0
Our study also found that As exposure has a profound negative impact on DNA repair, decreasing positive expression for XRCC1, MGMT, and hMSH2 mRNA with the increasing severity of skin lesion in arsenicosis patients (Table 3).
Negative_regulation (positive) of Gene_expression (expression) of hMSH2 in skin
9) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852665 Disease Relevance 0.12 Pain Relevance 0
The tumor specimens showed no MLH1 expression but did show normal MSH2 expression. p53 was not expressed.
Negative_regulation (p53) of Gene_expression (expression) of MSH2 in MLH1 associated with cancer
10) Confidence 0.35 Published 2007 Journal J Nippon Med Sch Section Abstract Doc Link 17878704 Disease Relevance 2.67 Pain Relevance 0.10
Inactivation of the mismatch repair gene MLH1 by methylation of the promoter seems to be the most frequent cause of MI in sporadic endometrioid carcinomas, followed by a loss of the expression of other two mismatch repair genes, the MSH2 and MSH6 genes.
Negative_regulation (loss) of Gene_expression (expression) of MSH2 in MLH1 associated with endometroid carcinoma and microsatellite instability
11) Confidence 0.25 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 2.16 Pain Relevance 0
These preliminary data suggest that lower MSH2 expression in the normal colonic mucosa, at least in the ascending colon and rectum, may be associated with increased risk of incident, sporadic colorectal adenoma as well as with modifiable risk factors for colorectal neoplasms, thus supporting further investigation of MSH2 expression as a potential modifiable biomarker of risk for colorectal neoplasms.
Negative_regulation (lower) of in ascending colon Gene_expression (expression) of MSH2 in rectum associated with colorectal cancer and adenoma
12) Confidence 0.15 Published 2009 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 19861524 Disease Relevance 0.85 Pain Relevance 0.09
In fact, Zhu and coworkers [10] also described abnormal hMSH-2 expression in about one-third of cases of AML, mainly in those with treatment-related secondary AML and in patients who were elderly.
Negative_regulation (abnormal) of Gene_expression (expression) of hMSH-2 associated with myeloid leukemia
13) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064099 Disease Relevance 0.98 Pain Relevance 0
Furthermore, it is possible that these alterations are associated with a chemotherapy-induced decrease in the expression of hMSH2.
Negative_regulation (decrease) of Gene_expression (expression) of hMSH2
14) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064099 Disease Relevance 1.12 Pain Relevance 0
We believe that the transient decrease in hMSH2 expression that we noted might have predisposed to an increased number of MSI events.
Negative_regulation (decrease) of Gene_expression (expression) of hMSH2 associated with microsatellite instability
15) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064099 Disease Relevance 0.99 Pain Relevance 0
We conclude that systemic chemotherapy may induce MSI and loss of heterozygosity in peripheral blood mononuclear cells from breast cancer patients receiving alkylating agents, possibly mediated by a chemotherapy-induced decrease in the expression of hMSH2.
Negative_regulation (decrease) of Gene_expression (expression) of hMSH2 in mononuclear cells associated with breast cancer and microsatellite instability
16) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Abstract Doc Link PMC1064099 Disease Relevance 0.90 Pain Relevance 0
Of particular note, 8/14 (57%) of the MMR-deficient CRCs had experienced the exclusive loss of either hPMS2 (n = 3) or hMSH6 (n = 5), without the respective loss of expression of hMLH1 or hMSH2.
Negative_regulation (loss) of Gene_expression (expression) of hMSH2
17) Confidence 0.01 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.84 Pain Relevance 0

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