INT146546

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 22.91
Pain Relevance 1.15

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RNA binding (MSI1) nucleus (MSI1) cytoplasm (MSI1)
Anatomy Link Frequency
neurons 2
astrocytes 2
oligodendrocytes 2
germline 1
stem cells 1
MSI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 200 82.12 Quite High
ischemia 24 80.76 Quite High
gABA 25 78.48 Quite High
Glutamate 15 75.12 Quite High
Piles 3 75.00 Quite High
tetrodotoxin 22 74.08 Quite High
Action potential 17 72.24 Quite High
Serotonin 4 71.28 Quite High
Pain 3 62.84 Quite High
Central nervous system 14 44.72 Quite Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 368 100.00 Very High Very High Very High
Hyperplasia 128 99.98 Very High Very High Very High
Cancer 806 99.80 Very High Very High Very High
Endometrial Cancer 1071 99.60 Very High Very High Very High
Familial Adenomatous Polyposis 26 99.24 Very High Very High Very High
Colon Cancer 93 98.46 Very High Very High Very High
Colorectal Cancer 190 97.80 Very High Very High Very High
Endometrial Hyperplasia 28 97.12 Very High Very High Very High
Malignant Neoplastic Disease 141 95.00 High High
Lichen Sclerosus Et Atrophicus 32 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These MSC-derived neurospheres expressed characteristic NSC antigens, such as nestin and musashi-1, and were capable of self-renewal and multilineage differentiation into neurons, astrocytes, and oligodendrocytes.
Gene_expression (expressed) of musashi-1 in oligodendrocytes
1) Confidence 0.48 Published 2008 Journal Stem Cells Dev. Section Abstract Doc Link 18426339 Disease Relevance 0.16 Pain Relevance 0.11
These MSC-derived neurospheres expressed characteristic NSC antigens, such as nestin and musashi-1, and were capable of self-renewal and multilineage differentiation into neurons, astrocytes, and oligodendrocytes.
Gene_expression (expressed) of musashi-1 in astrocytes
2) Confidence 0.16 Published 2008 Journal Stem Cells Dev. Section Abstract Doc Link 18426339 Disease Relevance 0.16 Pain Relevance 0.11
These MSC-derived neurospheres expressed characteristic NSC antigens, such as nestin and musashi-1, and were capable of self-renewal and multilineage differentiation into neurons, astrocytes, and oligodendrocytes.
Gene_expression (expressed) of musashi-1 in neurons
3) Confidence 0.16 Published 2008 Journal Stem Cells Dev. Section Abstract Doc Link 18426339 Disease Relevance 0.16 Pain Relevance 0.11
After plating, the rosette derived progenitors gave rise to an outgrowth of highly enriched bipolar cells expressing TUJ1, MUSASHI, NESTIN, A2B5, and MAP2 markers typically present in hESC-derived neural progenitors [14].
Gene_expression (expressing) of MUSASHI in neural
4) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0
Five microsatellite loci were examined using the tumor specimens to detect MSI, namely two loci with mononucleotide runs (i.e., BAT25 and BAT26) and three loci with dinucleotide repeats (i.e., APC, Mfd15, and D2S123).
Gene_expression (detect) of MSI associated with cancer and microsatellite instability
5) Confidence 0.10 Published 2007 Journal J Nippon Med Sch Section Abstract Doc Link 17878704 Disease Relevance 2.41 Pain Relevance 0.10
At D28 the cells were positive for the following neuroectodermal markers: Nestin (data not shown), Musashi-1 (Figure 2B), A2B5 (Figure 2C) and MAP2 (Figure 2D).
Gene_expression (positive) of Musashi
6) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346555 Disease Relevance 0 Pain Relevance 0.11
Nieminen et al. [26] studied serial endometrial biopsy samples taken during a 10-year followup of HPNCC mutation carriers and found abnormal MMR protein expression, MSI, or tumor suppressor promotor hypermethylation in various endometrial histologies, including normal and hyperplastic endometria.
Gene_expression (expression) of MSI associated with cancer, microsatellite instability and hyperplasia
7) Confidence 0.08 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 2.22 Pain Relevance 0
-catenin, KRAS, and MSI are present, with PTEN inactivation occuring in about 50% of the cases.
Gene_expression (present) of MSI associated with microsatellite instability
8) Confidence 0.08 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.63 Pain Relevance 0
A large population-based study revealed that a fecal DNA panel consisting of 21 mutations (three in the K-ras gene, 10 in the APC gene, and eight in the p53 gene; the MSI markers of BAT-26; and L-DNA) detects a greater proportion of CRC than FOBT without compromising specificity [29].
Gene_expression (markers) of MSI associated with colorectal cancer, familial adenomatous polyposis and microsatellite instability
9) Confidence 0.08 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.51 Pain Relevance 0
There are several MSI markers, among which BAT26 is probably the most widely used.
Gene_expression (markers) of MSI associated with microsatellite instability
10) Confidence 0.08 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.75 Pain Relevance 0
In addition, identical PTEN mutations have been also identified in hyperplasias coexisting with MSI-positive endometrioid endometrial carcinoma, which suggests that PTEN mutations are early events in their development [8].
Gene_expression (coexisting) of MSI associated with microsatellite instability, endometrial cancer and hyperplasia
11) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.54 Pain Relevance 0
Thus, some PTEN mutations may precede MSI, and coexistence of both alterations does not necessarily mean a cause-effect relationship [9].
Gene_expression (precede) of MSI associated with microsatellite instability
12) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.44 Pain Relevance 0
RII), BAX, insulin-like growth factor II receptor (IGFIIR), MSH3, MSH6, caspase-5, and PTEN may promote MSI-positive endometrial carcinoma [8, 9].
Gene_expression (promote) of MSI associated with microsatellite instability and endometrial cancer
13) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.74 Pain Relevance 0
On the other hand, identical PTEN mutations have been detected in MSI-negative endometrial hyperplasia with coexisting MSI-positive endometrioid endometrial carcinomas.
Neg (negative) Gene_expression (detected) of MSI associated with microsatellite instability and endometrial cancer
14) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.54 Pain Relevance 0
Interestingly, concordance between MSI status and PTEN mutations has been found; the mutations occur in 60–86% of MSI-positive endometrioid endometrial carcinoma but in only 24–35% of the MSI-negative cases [7–9, 13, 17].
Gene_expression (status) of MSI associated with microsatellite instability and endometrial cancer
15) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.33 Pain Relevance 0
Thus, recognition of newly diagnosed CRC patients that meet Bethesda Criteria should lead to evaluation with IHC and MSI testing of the tumor, as well as possible germline testing, despite a family history that does not satisfy Amsterdam Criteria.
Gene_expression (testing) of MSI in germline associated with cancer, colon cancer and microsatellite instability
16) Confidence 0.06 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2795749 Disease Relevance 0.95 Pain Relevance 0
It has a different set of genetic alterations than those in the first pathway, including p53 mutations, allelic imbalances (AI), and microsatellite instability (MSI).
Gene_expression (mutations) of MSI associated with microsatellite instability
17) Confidence 0.04 Published 2011 Journal Journal of Skin Cancer Section Abstract Doc Link PMC3003991 Disease Relevance 1.98 Pain Relevance 0
Despite robust MUSASHI and SOX1 expression, we found that addition of SB431542 failed to induce high levels of PAX6 expression (6.7±1% PAX6 positive cells at day 8 compared to 31.2±3.4% in control conditions, Fig. 2C).
Gene_expression (expression) of MUSASHI
18) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752165 Disease Relevance 0 Pain Relevance 0
One of the cell lines, HM3.B10 (B10), was found to differentiate into neural cell types including neural stem cells, neurons, astrocytes and oligodendrocytes in vitro as shown by expression of genetic markers for neural stem cells (nestin and Musashi1), neurons (neurofilament protein, synapsin and MAP2), astrocytes (glial fibrillary acidic protein, GFAP) and oligodendrocytes (myelin basic protein, MBP) as determined by RT-PCR assay.
Gene_expression (expression) of Musashi1 in astrocytes
19) Confidence 0.01 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2092394 Disease Relevance 0.60 Pain Relevance 0.15
One of the cell lines, HM3.B10 (B10), was found to differentiate into neural cell types including neural stem cells, neurons, astrocytes and oligodendrocytes in vitro as shown by expression of genetic markers for neural stem cells (nestin and Musashi1), neurons (neurofilament protein, synapsin and MAP2), astrocytes (glial fibrillary acidic protein, GFAP) and oligodendrocytes (myelin basic protein, MBP) as determined by RT-PCR assay.
Gene_expression (expression) of Musashi1 in stem cells
20) Confidence 0.00 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2092394 Disease Relevance 0.60 Pain Relevance 0.15

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