INT146553

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 2.56
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rock2) cytoskeleton (Rock2) nucleus (Rock2)
kinase activity (Rock2) cytoplasm (Rock2)
Anatomy Link Frequency
nerve 1
platelets 1
Rock2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 3 99.32 Very High Very High Very High
fibrosis 15 98.62 Very High Very High Very High
Thermal hyperalgesia 4 97.16 Very High Very High Very High
epidural 1 84.72 Quite High
Sciatic nerve 2 83.00 Quite High
cva 1 81.16 Quite High
Neuropathic pain 11 78.96 Quite High
intrathecal 1 76.00 Quite High
anesthesia 2 71.12 Quite High
antagonist 15 25.52 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 12 99.92 Very High Very High Very High
Pulmonary Fibrosis 7 98.62 Very High Very High Very High
Interstitial Lung Diseases 4 98.08 Very High Very High Very High
Hyperalgesia 4 97.16 Very High Very High Very High
Age-related Macular Degeneration 1 90.96 High High
Thrombosis 4 87.32 High High
Cv General 3 Under Development 1 81.16 Quite High
Neuropathic Pain 13 75.00 Quite High
Targeted Disruption 15 74.88 Quite High
Embryonic Lethality 4 74.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, these findings suggest that a long-lasting activation of PKC and RhoA/Rho kinase pathways in the spinal cord may be responsible for the development of thermal hyperalgesia induced by nerve ligation in mice.
Positive_regulation (activation) of Rho kinase in nerve associated with thermal hyperalgesia and spinal cord
1) Confidence 0.44 Published 2007 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 17879593 Disease Relevance 0.49 Pain Relevance 0.81
PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation.
Positive_regulation (activation) of RhoA/Rho kinase associated with fibrosis, pulmonary hypertension and pulmonary fibrosis
2) Confidence 0.07 Published 2008 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Title Doc Link 17965319 Disease Relevance 0.83 Pain Relevance 0.12
PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation.
Positive_regulation (activation) of RhoA/Rho kinase associated with fibrosis, pulmonary hypertension and pulmonary fibrosis
3) Confidence 0.07 Published 2008 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Title Doc Link 17965319 Disease Relevance 0.83 Pain Relevance 0.12
Nanomolar concentrations of LPA and minimally oxidized LDL induce shape change of washed platelets through LPA receptor-linked signal transduction pathways that presumably involve the activation of the heterotrimeric G12/G13 protein, the small GTPase Rho and Rho kinase, the Rho kinase-mediated inhibition of myosin light-chain phosphatase, and stimulation of myosin light-chain phosphorylation (Bauer et al., 1999; Retzer and Essler, 2000; Retzer et al., 2000).
Positive_regulation (activation) of Rho kinase in platelets
4) Confidence 0.02 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.41 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox