INT146594

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 18.88
Pain Relevance 5.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
cartilage 4
visceral 2
blood 2
plasma 2
platelet 2
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 443 100.00 Very High Very High Very High
cINOD 29 100.00 Very High Very High Very High
Kinase C 36 99.08 Very High Very High Very High
Inflammation 93 98.88 Very High Very High Very High
spinal inflammation 9 98.48 Very High Very High Very High
Calcium channel 2 97.84 Very High Very High Very High
dexamethasone 10 97.28 Very High Very High Very High
spondylitis 2 96.60 Very High Very High Very High
Pain 102 94.96 High High
Inflammatory response 6 94.04 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 457 100.00 Very High Very High Very High
Obesity 760 99.80 Very High Very High Very High
Neuropathic Pain 1 99.52 Very High Very High Very High
Mycobacterial Infection 164 99.44 Very High Very High Very High
Hyperlipidemia 4 99.38 Very High Very High Very High
Coronary Artery Disease 10 99.28 Very High Very High Very High
Sleep Disorders 8 99.10 Very High Very High Very High
INFLAMMATION 113 98.88 Very High Very High Very High
Weight Loss 159 98.80 Very High Very High Very High
Low Back Pain 12 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with this observation, valsartan, another ARB, aside from lowering blood pressure, decreased leptin levels and BMI in obese individuals, when compared with the calcium channel blocker (CCB) felodipine (Fogari et al 2005).
Negative_regulation (decreased) of Gene_expression (levels) of leptin in blood associated with calcium channel and obesity
1) Confidence 0.42 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 1.26 Pain Relevance 0.11
Similarly, the angiotensin-converting enzyme (ACE) inhibitor, enalapril, in combination with a weight reduction program, evidenced the greatest benefits in terms of weigh loss and diminution of plasma norepinephrine, insulin, and leptin levels in comparison with control groups treated with weight reduction program alone or combined with the CCB amlodipine (Masuo et al 2001).
Negative_regulation (loss) of Gene_expression (levels) of leptin in plasma associated with weight loss
2) Confidence 0.42 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 1.15 Pain Relevance 0.19
higher posttreatment leptin levels (4.38±2.95 versus 3.18±4.26 ng/mL) than the male patients, they were not
Neg (not) Negative_regulation (were) of Gene_expression (levels) of leptin
3) Confidence 0.41 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.43 Pain Relevance 0.03
probably low leptin concentrations may contribute to the increased
Negative_regulation (low) of Gene_expression (concentrations) of leptin
4) Confidence 0.41 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.81 Pain Relevance 0.04
not know whether low leptin concentration has any contribution in
Spec (whether) Negative_regulation (low) of Spec (whether) Gene_expression (concentration) of leptin
5) Confidence 0.41 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.82 Pain Relevance 0.05
postreatment leptin levels of the patients were still
Negative_regulation (were) of Gene_expression (levels) of leptin
6) Confidence 0.41 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.41 Pain Relevance 0.03
g/mL) IL-6, IL-8, and PGE2 production was studied by inhibiting leptin-induced endogenous NO production with a selective iNOS inhibitor 1400 W (1 mM) during a 48 hour incubation of OA explants from 8 patients.
Negative_regulation (inhibiting) of Neg (NO) Gene_expression (production) of leptin-induced associated with osteoarthritis
7) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.28 Pain Relevance 0.14
A selective iNOS inhibitor 1400 W (1 mM) inhibited leptin-induced NO production almost completely indicating that it was synthesized through iNOS pathway (Figure 4(a)).
Negative_regulation (inhibited) of Neg (NO) Gene_expression (production) of leptin-induced
8) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.25 Pain Relevance 0.14
The expression of leptin and its functional receptor is strongly up-regulated in human OA cartilage and is related to the grade of cartilage destruction [9,10].
Negative_regulation (related) of Gene_expression (expression) of leptin in cartilage associated with osteoarthritis
9) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.26 Pain Relevance 0.41
M) significantly inhibited leptin-induced NO, PGE2, IL-6, and IL-8 production (Figure 3).
Negative_regulation (inhibited) of Gene_expression (production) of leptin-induced
10) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.29 Pain Relevance 0.21
In the present study, inhibition of leptin-induced endogenous NO production in OA cartilage with a selective iNOS inhibitor 1400 W also suppressed the effects of leptin on PGE2, IL-6, and IL-8 production.
Negative_regulation (inhibition) of Gene_expression (production) of leptin-induced in cartilage associated with osteoarthritis
11) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.50 Pain Relevance 0.43
Leptin-induced IL-6 and IL-8 production was reduced by inhibitors of JNK, PKC, and NF-?
Negative_regulation (reduced) of Gene_expression (production) of Leptin-induced associated with kinase c
12) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.48 Pain Relevance 0.44
Leptin-induced NO production was suppressed by inhibitors of JNK, JAK3, PKC, and NF-?
Negative_regulation (suppressed) of Gene_expression (production) of Leptin-induced associated with kinase c
13) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.36 Pain Relevance 0.38
Ingredients in this proprietary blend not only lowered serum leptin levels but also reduced CRP, a key marker for low grade inflammation.
Negative_regulation (lowered) of Gene_expression (levels) of serum leptin associated with inflammation
14) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.92 Pain Relevance 0.22
A significant group × time interaction was found for serum leptin (P < 0.05), with significant reductions occurring after the initial phase of dietary restriction.
Negative_regulation (reductions) of Gene_expression (found) of serum leptin
15) Confidence 0.35 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2693519 Disease Relevance 0.51 Pain Relevance 0
As observed in the Sartorio study, serum leptin changes in the present study mimicked body mass changes and significantly decreased in all groups (except CON) after 2 weeks (Table 4).
Negative_regulation (decreased) of Gene_expression (changes) of serum leptin in body
16) Confidence 0.35 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2693519 Disease Relevance 0.22 Pain Relevance 0
Like in the case of the other parameters measured, C-reactive protein and leptin levels decreased over time in both groups.
Negative_regulation (decreased) of Gene_expression (levels) of leptin
17) Confidence 0.35 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2651880 Disease Relevance 0.24 Pain Relevance 0
between subjective sensation and LEP amplitude; however,
Negative_regulation (sensation) of Gene_expression (amplitude) of LEP
18) Confidence 0.34 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2271124 Disease Relevance 0.77 Pain Relevance 0.77
domain corresponds to the extracted LEP peak) with that of the prestimulus
Negative_regulation (extracted) of Gene_expression (peak) of LEP
19) Confidence 0.34 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2271124 Disease Relevance 0 Pain Relevance 0
Leptin production was reduced in contrast with normal levels of adiponectin.
Negative_regulation (reduced) of Gene_expression (production) of Leptin
20) Confidence 0.33 Published 2007 Journal Metab. Clin. Exp. Section Abstract Doc Link 17884449 Disease Relevance 1.25 Pain Relevance 0.80

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