INT146611

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.34
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Ins1, Akt1) cytoplasm (Ins1, Akt1) transport (Akt1)
aging (Akt1) enzyme binding (Akt1) cytosol (Akt1)
Anatomy Link Frequency
muscle 4
adipocyte 2
Ins1 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 2 90.76 High High
cytokine 44 83.44 Quite High
Versed 3 78.44 Quite High
tolerance 38 77.20 Quite High
Inflammation 84 50.00 Quite Low
anesthesia 8 15.28 Low Low
agonist 22 5.00 Very Low Very Low Very Low
chemokine 14 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 206 99.64 Very High Very High Very High
Targeted Disruption 112 98.20 Very High Very High Very High
Dislocations 3 96.08 Very High Very High Very High
Insulin Resistance 187 95.48 Very High Very High Very High
Shock 92 94.48 High High
Body Weight 24 92.64 High High
Peripheral Arterial Disease 3 91.56 High High
Hyperinsulinism 11 83.44 Quite High
Impaired Glucose Tolerance 28 76.32 Quite High
Hypertrophy 20 62.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Akt phosphorylation induced by insulin was enhanced upon Hsp72 overexpression (Fig. 9A,B).
insulin Positive_regulation (induced) of Phosphorylation (phosphorylation) of Akt
1) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.55 Pain Relevance 0
Insulin stimulated phosphorylation of PKB at serine 473 was measured and corrected for total PKB.


Insulin Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of PKB
2) Confidence 0.21 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.10 Pain Relevance 0.04
Diminished insulin-activated Akt phosphorylation in muscle from HFD-fed WT compared to 12/15LO KO mice
insulin Positive_regulation (activated) of Phosphorylation (phosphorylation) of Akt in muscle associated with targeted disruption
3) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.02 Pain Relevance 0
As expected, acute insulin treatment induced phosphorylation of Akt in both groups (Figure 5).
insulin Positive_regulation (induced) of Phosphorylation (phosphorylation) of Akt
4) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 0.96 Pain Relevance 0
AKT phosphorylation at Ser473 and Thr308 was enhanced in Ad-shPck1–treated animals after insulin treatment, in marked contrast to reduced signaling by insulin in saline-treated and Ad-shCT–treated groups (Fig. 3C–H).
insulin Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of AKT
5) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.35 Pain Relevance 0.07
In contrast, chronic treatment (48 h) with IL-6 completely impaired insulin-induced AKT phosphorylation without changes in the amount of total AKT protein in wild-type mice (Fig. 6D).
insulin Positive_regulation (induced) of Phosphorylation (phosphorylation) of AKT
6) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.34 Pain Relevance 0.11
Insulin-stimulated Akt phosphorylation was enhanced in ?
Insulin Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of Akt
7) Confidence 0.06 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.40 Pain Relevance 0
Evodiamine treatment also reduced insulin-stimulated phosphorylation of Akt, a crucial regulator of adipocyte differentiation; and the reduction of phosphorylated-Akt and augmentation of phosphorylated ERK were reversed by blockade of the MAPK kinase/MAPK signaling pathway, restoring adipogenesis in the cultures.
insulin Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of Akt in adipocyte
8) Confidence 0.06 Published 2008 Journal Endocrinology Section Abstract Doc Link 17884939 Disease Relevance 0.39 Pain Relevance 0.16
In the SOL muscle, there was no effect of PTEN ablation on insulin stimulated PKB Thr308 phosphorylation (Figure S2).
insulin Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of PKB in muscle
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.23 Pain Relevance 0

General Comments

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