INT146660

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.01
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsk) extracellular space (Ctsk) lysosome (Ctsk)
cytoplasm (Ctsk)
Anatomy Link Frequency
arcuate nucleus 2
osteoclast 1
epithelial cells 1
fibroblasts 1
lung 1
Ctsk (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 8 98.28 Very High Very High Very High
metalloproteinase 71 98.08 Very High Very High Very High
Arthritis 113 96.00 Very High Very High Very High
rheumatoid arthritis 92 94.72 High High
Inflammation 70 93.88 High High
fibrosis 274 91.24 High High
cytokine 46 79.64 Quite High
Opioid 2 65.60 Quite High
backache 1 58.20 Quite High
anesthesia 4 51.40 Quite High
Disease Link Frequency Relevance Heat
Pycnodysostosis 6 99.74 Very High Very High Very High
Osteoporosis 34 99.12 Very High Very High Very High
Apoptosis 46 97.20 Very High Very High Very High
Arthritis 118 96.00 Very High Very High Very High
Death 5 94.96 High High
Rheumatoid Arthritis 92 94.72 High High
Stress 1 94.64 High High
INFLAMMATION 74 93.88 High High
Spondylolysis 1 92.56 High High
Bone Cancer 53 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent reports from our group showed that mice deficient of cathepsin K responded with a significantly increased extracellular matrix deposition to challenge with bleomycin when compared to wild-type mice with a normal cath K expression, thus for the first time suggesting a protective role of cathepsin K in lung matrix homeostasis under physiological and pathological conditions [8].
Negative_regulation (deficient) of cathepsin K in lung
1) Confidence 0.43 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.73 Pain Relevance 0.12
In contrast, freshly prepared, primary type II alveolar epithelial cells of both wild-type and cath K tg mice completely lacked cathepsin K protein (Figure 1C).
Negative_regulation (lacked) of cathepsin K in epithelial cells
2) Confidence 0.37 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.16 Pain Relevance 0.05
Pamidronate treatment increased TRAP stained osteoclast numbers yet decreased cathepsin K indicating that pamidronate repressed osteoclast maturation and function.
Negative_regulation (decreased) of cathepsin K in osteoclast
3) Confidence 0.37 Published 2008 Journal The Open Orthopaedics Journal Section Abstract Doc Link PMC2703200 Disease Relevance 0.25 Pain Relevance 0
The dramatic improvement achieved by calcitonin therapy might be related to osteoclastic dysfunction in pycnodysostosis caused by a deficiency of cathepsin K, a cystein protease involved in bone matrix remodelling.
Negative_regulation (deficiency) of cathepsin K associated with osteoporosis and pycnodysostosis
4) Confidence 0.20 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 17891524 Disease Relevance 1.21 Pain Relevance 0.06
In support of a functional role of the observed formation of met-enkephalin on the expense of beta-EP increased numbers of cathepsin K immunoreactive cells, but diminished numbers of both beta-EP-positive cells and double-positive (cathepsin K/beta-EP) cells were found in left and right arcuate nucleus of schizophrenics.
Negative_regulation (numbers) of cathepsin K in arcuate nucleus associated with enkephalin
5) Confidence 0.13 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19428782 Disease Relevance 0.41 Pain Relevance 0.37
In support of a functional role of the observed formation of met-enkephalin on the expense of beta-EP increased numbers of cathepsin K immunoreactive cells, but diminished numbers of both beta-EP-positive cells and double-positive (cathepsin K/beta-EP) cells were found in left and right arcuate nucleus of schizophrenics.
Negative_regulation (diminished) of cathepsin K in arcuate nucleus associated with enkephalin
6) Confidence 0.13 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19428782 Disease Relevance 0.41 Pain Relevance 0.37
CATk inhibitors have been shown in animal studies to increase cortical thickness and periosteal bone formation and are currently undergoing phase 3 trials.
Negative_regulation (inhibitors) of CATk
7) Confidence 0.08 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.37 Pain Relevance 0.04
CATk inhibitors have an antiresorptive effect, with lesser inhibition of bone formation than bisphosphonates.
Negative_regulation (inhibitors) of CATk
8) Confidence 0.08 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.45 Pain Relevance 0.05
This degenerative property of fibroblasts was prevented by a potent cathepsin K inhibitor.
Negative_regulation (inhibitor) of cathepsin K in fibroblasts
9) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.74 Pain Relevance 0.39
IL-17, IL-12, cathepsin K and osteoprotegrin ligand mRNA levels were also reduced [86, 87].
Negative_regulation (reduced) of cathepsin K
10) Confidence 0.03 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.29 Pain Relevance 0.62

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox