INT146686

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (App, Aph1a) peptidase activity (Aph1a) endoplasmic reticulum (Aph1a)
cell adhesion (App) plasma membrane (App) extracellular matrix organization (App)
Anatomy Link Frequency
Notch 1
App (Mus musculus)
Aph1a (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 2 100.00 Very High Very High Very High
cINOD 1 98.82 Very High Very High Very High
Hippocampus 1 48.88 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 3 100.00 Very High Very High Very High
INFLAMMATION 1 98.70 Very High Very High Very High
Targeted Disruption 2 76.64 Quite High
Disease 2 75.00 Quite High
Toxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some nonsteroidal anti-inflammatory drugs has been shown to allosterically modulate the activity of gamma-secretase, the enzymatic complex responsible for the formation of beta-amyloid (Abeta). 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074) is a new gamma-secretase modulator, devoid of anticyclooxygenase (COX) and Notch-interfering activities in vitro.
Abeta Binding (formation) of gamma-secretase in Notch associated with inflammation, alzheimer's dementia, cinod and abeta
1) Confidence 0.14 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17895400 Disease Relevance 0.58 Pain Relevance 0.19

General Comments

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