INT146693

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 10.99
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Mbl1) extracellular region (Mbl1)
Anatomy Link Frequency
plasma 2
liver 2
synovial fluid 1
bowel 1
heart 1
Mbl1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 715 99.76 Very High Very High Very High
spastic colon 12 98.78 Very High Very High Very High
Inflammation 104 96.16 Very High Very High Very High
spinal inflammation 14 84.48 Quite High
Arthritis 195 83.08 Quite High
ischemia 13 63.04 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 715 99.76 Very High Very High Very High
Reprotox - General 3 18 99.08 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

10 98.78 Very High Very High Very High
Functional Bowel Disorder 2 98.68 Very High Very High Very High
Celiac Disease 16 98.40 Very High Very High Very High
Coronary Artery Disease 26 98.28 Very High Very High Very High
Infection 80 97.76 Very High Very High Very High
INFLAMMATION 91 96.16 Very High Very High Very High
Disease 377 94.84 High High
Arthritis 273 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with oligoarthritis carrying the low MBL expression genotype were more often in remission (81%) than patients in the medium (54%) and high (56%) genotype groups (P = 0.02; Table 4).
Gene_expression (expression) of MBL
1) Confidence 0.59 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.23 Pain Relevance 0.04
Mannose-binding lectin (MBL) is a serum protein, produced in the liver, that plays an important role in innate immunity and functions as an opsonin, recognizing sugar structures on a wide variety of micro-organisms [5].
Gene_expression (produced) of Mannose-binding lectin in liver
2) Confidence 0.59 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.78 Pain Relevance 0.30
Mannose-binding lectin (MBL) is a serum protein, produced in the liver, that plays an important role in innate immunity and functions as an opsonin, recognizing sugar structures on a wide variety of micro-organisms [5].
Gene_expression (produced) of MBL in liver
3) Confidence 0.59 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.77 Pain Relevance 0.30
Patients were classified into three MBL2 genotype groups with high, medium and low expression of MBL.
Gene_expression (expression) of MBL
4) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0 Pain Relevance 0
Therefore, patients can be classified into high (YA/YA and YA/XA), medium (XA/XA and YA/O) and low (XA/O and O/O) MBL genotype expression groups [10,14].
Gene_expression (expression) of MBL
5) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.53 Pain Relevance 0.11
MBL is present in synovial fluid and can bind potential causative agents in JRA including micro-organisms, cellular debris, and agalactosyl IgG (IgG-G0) [38,39].
Gene_expression (present) of MBL in synovial fluid associated with rheumatoid arthritis
6) Confidence 0.52 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.17 Pain Relevance 0.36
Based on the number of included patients and control individuals, this study has 80% power when an odds ratio of 1.71 or greater for MBL deficiency is found.
Gene_expression (deficiency) of MBL
7) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.99 Pain Relevance 0.35
Recently, Troelsen and colleagues [41] found that high serum levels of MBL and agalactosyl IgG were risk factors for ischaemic heart disease in RA patients.
Gene_expression (levels) of MBL in heart associated with coronary artery disease and rheumatoid arthritis
8) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.35 Pain Relevance 0.36
MBL assays
Gene_expression (assays) of MBL
9) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.30 Pain Relevance 0.03
However, only the X/Y variant has a pronounced influence; the X allele is associated with decreased plasma MBL levels and the Y variant with high plasma MBL levels.
Gene_expression (levels) of MBL in plasma
10) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.05 Pain Relevance 0
However, only the X/Y variant has a pronounced influence; the X allele is associated with decreased plasma MBL levels and the Y variant with high plasma MBL levels.
Gene_expression (levels) of MBL in plasma
11) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.06 Pain Relevance 0
Subsequently, intermediately decreased MBL serum levels are seen in individuals with the genotypes XA/XA and YA/O, whereas very low or undetectable serum MBL levels are seen in individuals with genotypes XA/O and O/O.
Gene_expression (levels) of MBL
12) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.25 Pain Relevance 0.03
MBL2 gene mutations were determined by Taqman analysis to identify genotypes with high, medium and low expression of MBL.
Gene_expression (expression) of MBL
13) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2453777 Disease Relevance 0.70 Pain Relevance 0.16
In this study, plasma levels of MBL were determined in patients with CD and irritable bowel syndrome (IBS) in order to investigate whether there is an association of MBL levels and the occurrence of SA in these patients.
Gene_expression (levels) of MBL in bowel associated with celiac disease, reprotox - general 3 and spastic colon
14) Confidence 0.34 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 18478332 Disease Relevance 1.37 Pain Relevance 0.48
These results suggest that the serum levels of MBL and the occurrence of SA in women with CD and IBS are not causally related.
Gene_expression (levels) of MBL associated with celiac disease, reprotox - general 3 and spastic colon
15) Confidence 0.26 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 18478332 Disease Relevance 1.48 Pain Relevance 0.52
Mannose binding lectin levels in spondyloarthropathies.
Gene_expression (levels) of Mannose binding lectin
16) Confidence 0.07 Published 2007 Journal J. Rheumatol. Section Title Doc Link 17896801 Disease Relevance 0.18 Pain Relevance 0.08
MS2-MBP (a gift from Robin Reed, Harvard University) was expressed in Escherichia coli DH5?.
Gene_expression (expressed) of MS2-MBP
17) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
Expression of the MS2-MBP (Maltose-binding Protein) Fusion Protein
Gene_expression (Expression) of MS2-MBP
18) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0

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