INT146701

Context Info Confidence 0.02 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.72 Pain Relevance 0.26

signal transduction (Nfkb1, TNF) mitochondrion (Nfkb1) intracellular (TNF) extracellular matrix organization (TNF) DNA binding (Nfkb1) protein complex (Nfkb1)

Nfkb1 (Mus musculus) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 4 98.94 spinal inflammation 1 84.72

Disease Link Frequency Relevance Heat Cancer 2 100.00 Necrosis 2 100.00 Disease 1 99.22 Rheumatoid Arthritis 4 98.94 Low Back Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

OBJECTIVE: Rheumatoid arthritis (RA) is a disease characterized by prolonged production of tumor necrosis factor-alpha (TNF-alpha), which is regulated by the Rel/nuclear factor-kappaB (NF-kappaB) transcription factors.

nuclear factor-kappaB Regulation (regulated) of Gene_expression (production) of TNF-alpha associated with necrosis, cancer, rheumatoid arthritis and disease

1) Confidence 0.02 Published 2007 Journal J. Rheumatol. Section Abstract Doc Link 17896809 Disease Relevance 0.72 Pain Relevance 0.26

General Comments

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