INT146742

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (GSR, PLA2G4A) cytosol (GSR, PLA2G4A) mitochondrion (GSR)
aging (PLA2G4A) small molecule metabolic process (GSR) Golgi apparatus (PLA2G4A)
Anatomy Link Frequency
fibroblasts 1
GSR (Homo sapiens)
PLA2G4A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 95.04 Very High Very High Very High
antagonist 1 55.32 Quite High
cINOD 1 32.80 Quite Low
Disease Link Frequency Relevance Heat
Necrosis 1 68.00 Quite High
Cancer 1 67.64 Quite High
INFLAMMATION 1 32.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, we demonstrated in this study that cortisol increased PLA2G4A mRNA level via GR-dependent ongoing transcription in human amnion fibroblasts by activating the binding of GR to PLA2G4A promoter directly, and this effect appeared unlikely to be secondary to the effect of cortisol on the expression of proinflammatory cytokines in human amnion fibroblasts.
GR Binding (binding) of PLA2G4A promoter in fibroblasts associated with cytokine
1) Confidence 0.28 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.14 Pain Relevance 0.11

General Comments

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