INT146747

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLA2G4A) aging (PLA2G4A) Golgi apparatus (PLA2G4A)
endoplasmic reticulum (PLA2G4A) cytoplasmic membrane-bounded vesicle (PLA2G4A) nucleus (PLA2G4A)
Anatomy Link Frequency
monocytes 2
fibroblasts 2
PLA2G4A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 88.76 High High
antagonist 1 82.40 Quite High
Inflammation 3 79.28 Quite High
cytokine 3 64.08 Quite High
Pain 1 62.20 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 88.52 High High
Pressure And Volume Under Development 1 63.00 Quite High
Fever 1 62.48 Quite High
Pain 1 62.20 Quite High
Cancer 2 61.28 Quite High
Necrosis 1 56.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was designed to examine the molecular mechanisms underlying glucocorticoid-induced PLA2G4A expression in human amnion fibroblasts.
Spec (examine) Negative_regulation (underlying) of Gene_expression (expression) of PLA2G4A in fibroblasts
1) Confidence 0.43 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.20 Pain Relevance 0.16
We conclude that the inhibitory effect of ellagic acid on PGE2 release from monocytes is due to a suppressed expression of COX-2, mPGEs-1 and cPLA2alpha, rather than a direct effect on the activities of these enzymes.
Negative_regulation (suppressed) of Gene_expression (expression) of cPLA2alpha in monocytes
2) Confidence 0.41 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.45 Pain Relevance 0.17

General Comments

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