INT146755

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.50
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcn2) extracellular space (Lcn2) extracellular region (Lcn2)
Anatomy Link Frequency
liver 1
nerve 1
kidney 1
Lcn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 8 99.32 Very High Very High Very High
Sciatic nerve 8 99.04 Very High Very High Very High
peripheral neuropathy 2 89.44 High High
Angina 5 75.00 Quite High
induced neuropathy 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Poisoning 2 99.58 Very High Very High Very High
Diabetes Mellitus 3 99.06 Very High Very High Very High
Acute Renal Failure 4 94.16 High High
Renal Disease 16 90.96 High High
Neuropathic Pain 6 75.00 Quite High
Cv General 3 Under Development 5 75.00 Quite High
Peripheral Neuropathy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes of p35 precursor, p35 and p25 contents in CC, SC and SN showed the same pattern with that of CDK5 activities.
Regulation (changes) of p25 associated with sciatic nerve and spinal cord
1) Confidence 0.26 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.29 Pain Relevance 0.44
Thus, HD intoxication was associated with deregulation of CDK5 and its activator p35 or p25 in nerve tissues.
Regulation (deregulation) of p25 in nerve associated with poisoning
2) Confidence 0.26 Published 2008 Journal Toxicology Section Abstract Doc Link 18423835 Disease Relevance 0.28 Pain Relevance 0.42
PURPOSE: The value of NGAL (neutrophil gelatinase-associated lipocalin) and L-FABP (liver-type fatty acid binding protein) has been highlighted as a novel biomarker of detection of acute renal failure in children after cardiac surgery.
Regulation (value) of NGAL in liver associated with acute renal failure
3) Confidence 0.20 Published 2009 Journal Adv Med Sci Section Abstract Doc Link 19875355 Disease Relevance 0.24 Pain Relevance 0.14
Serum creatinine level, the presence of diabetes, and the duration of the PCI may affect serum NGAL values and kidney function following a PCI procedure.
Regulation (values) of NGAL in kidney associated with diabetes mellitus
4) Confidence 0.17 Published 2007 Journal Kidney Blood Press. Res. Section Abstract Doc Link 17901710 Disease Relevance 0.59 Pain Relevance 0.07
We measured urinary and serum NGAL values before and 2, 4, 8, 24, and 48 h after the PCI.
Regulation (values) of NGAL
5) Confidence 0.17 Published 2007 Journal Kidney Blood Press. Res. Section Abstract Doc Link 17901710 Disease Relevance 0.55 Pain Relevance 0.07
We found a significant rise in serum NGAL levels 2, 4, and 8 h after the PCI and in urinary NGAL values 4, 8, and 24 h after a PCI procedure.
Regulation (values) of NGAL
6) Confidence 0.17 Published 2007 Journal Kidney Blood Press. Res. Section Abstract Doc Link 17901710 Disease Relevance 0.56 Pain Relevance 0.07

General Comments

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