INT146757

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 7.21
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LCN2)
Anatomy Link Frequency
mesangial cells 2
neutrophil 2
LCN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 16 99.24 Very High Very High Very High
Inflammation 57 99.20 Very High Very High Very High
ischemia 3 97.12 Very High Very High Very High
Angina 1 95.40 Very High Very High Very High
cytokine 14 93.72 High High
Arthritis 15 86.36 High High
chemokine 12 65.40 Quite High
Inflammatory mediators 11 54.12 Quite High
fibrosis 16 36.00 Quite Low
rheumatoid arthritis 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 347 99.72 Very High Very High Very High
Stress 64 99.32 Very High Very High Very High
INFLAMMATION 84 99.20 Very High Very High Very High
Injury 18 99.08 Very High Very High Very High
Adhesions 8 98.80 Very High Very High Very High
Systemic Lupus Erythematosus 258 98.40 Very High Very High Very High
Chronic Renal Failure 9 98.36 Very High Very High Very High
Apoptosis 46 98.12 Very High Very High Very High
Toxicity 40 98.04 Very High Very High Very High
Disease 89 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition upregulation of NGAL expression under oxidative stress condition has recently been demonstrated and it has proposed a new function for NGAL such as a protective factor against free radicals produced by H2O2, oxidant compounds [27, 28].
Positive_regulation (upregulation) of Gene_expression (expression) of NGAL associated with stress
1) Confidence 0.69 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.81 Pain Relevance 0.08
But following the increasing folds in mRNA the NGAL protein expression due to unknown reason does not increased and this is the main reason for unconvalesce in this disease.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of NGAL associated with disease
2) Confidence 0.69 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.36 Pain Relevance 0
The overexpression of NGAL has been shown to reduce the adhesion and invasion of cancer cells in vitro and in vivo [31, 32].
Positive_regulation (overexpression) of Gene_expression (overexpression) of NGAL associated with cancer and adhesions
3) Confidence 0.69 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.88 Pain Relevance 0.14
A recent work has shown that NGAL expression was dramatically upregulated in kidney mesangial cells derived from lupus-prone mice after in vitro treatment with the murine nephritogenic anti-dsDNA monoclonal antibodies [26].
Positive_regulation (upregulated) of Gene_expression (expression) of NGAL in mesangial cells associated with systemic lupus erythematosus
4) Confidence 0.53 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.13 Pain Relevance 0.14
To investigate whether SM induces NGAL expression in protein level immunohistochemistry was performed.
Spec (whether) Positive_regulation (induces) of Gene_expression (expression) of NGAL
5) Confidence 0.47 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0 Pain Relevance 0
Numerical data are expressed as mean ± SD of fold changes of NGAL gene expression in three independent experiments.
Positive_regulation (changes) of Gene_expression (expression) of NGAL
6) Confidence 0.47 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0 Pain Relevance 0
Our results in the present study revealed that the expression of NGAL at mRNA levels was upregulated significantly in airways of SM-exposed patients in comparison with unexposed control group.
Positive_regulation (upregulated) of Gene_expression (expression) of NGAL
7) Confidence 0.41 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.21 Pain Relevance 0.03
Our result showed that expression of NGAL in mRNA level increased from 1.4- to 9.8-folds compared with the control samples (Table 3).
Positive_regulation (increased) of Gene_expression (expression) of NGAL
8) Confidence 0.41 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0 Pain Relevance 0
While Normal control samples expressed same level of mRNA NGAL, expression level of mRNA-NGAL was upregulated about 1.4- to 9.8-folds compared to normal samples.
Positive_regulation (upregulated) of Gene_expression (expression) of NGAL
9) Confidence 0.41 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2873661 Disease Relevance 0.25 Pain Relevance 0
NGAL is constitutively expressed at low levels in the kidneys [18] but upregulated following acute renal injury and various insults such as inflammation, ischemia, and infection [19–22].
Positive_regulation (upregulated) of Gene_expression (expressed) of NGAL associated with inflammation, ischemia, injury and infection
10) Confidence 0.38 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.11 Pain Relevance 0.16
Patients with worsening global or renal disease activity had increased levels of uNGAL and NGAL/creatinine.
Positive_regulation (increased) of Gene_expression (levels) of uNGAL associated with renal disease
11) Confidence 0.35 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.89 Pain Relevance 0.08
Could neutrophil-gelatinase-associated lipocalin and cystatin C predict the development of contrast-induced nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine values?
Positive_regulation (Could) of Gene_expression (predict) of lipocalin in neutrophil associated with angina and renal disease
12) Confidence 0.01 Published 2007 Journal Kidney Blood Press. Res. Section Title Doc Link 17901710 Disease Relevance 0.56 Pain Relevance 0.10

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