INT146758

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 45
Total Number 46
Disease Relevance 38.29
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LCN2)
Anatomy Link Frequency
liver 3
epithelial cells 3
Urine 2
kidney 2
plasma 1
LCN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 227 99.86 Very High Very High Very High
Inflammatory response 68 98.60 Very High Very High Very High
Arthritis 60 97.08 Very High Very High Very High
Angina 3 95.40 Very High Very High Very High
ischemia 20 95.12 Very High Very High Very High
cytokine 95 93.72 High High
addiction 2 89.68 High High
rheumatoid arthritis 60 84.64 Quite High
anesthesia 5 84.48 Quite High
chemokine 56 79.24 Quite High
Disease Link Frequency Relevance Heat
Injury 584 100.00 Very High Very High Very High
INFLAMMATION 337 99.86 Very High Very High Very High
Renal Disease 1503 99.84 Very High Very High Very High
Autosomal Dominant Polycystic Kidney 222 99.36 Very High Very High Very High
Stress 174 99.32 Very High Very High Very High
Acute-phase Reaction 3 99.04 Very High Very High Very High
Systemic Lupus Erythematosus 1032 99.00 Very High Very High Very High
Colon Cancer 30 98.88 Very High Very High Very High
Adhesions 37 98.80 Very High Very High Very High
Chronic Renal Failure 134 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the mRNA level, the present study showed the localization of NGAL in bronchial epithelial cells in SM-exposed and unexposed patients; no significant expression level of NGAL protein was detected in both groups.
Gene_expression (expression) of NGAL in epithelial cells
1) Confidence 0.78 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.42 Pain Relevance 0.06
In addition upregulation of NGAL expression under oxidative stress condition has recently been demonstrated and it has proposed a new function for NGAL such as a protective factor against free radicals produced by H2O2, oxidant compounds [27, 28].
Gene_expression (expression) of NGAL associated with stress
2) Confidence 0.78 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.81 Pain Relevance 0.08
But following the increasing folds in mRNA the NGAL protein expression due to unknown reason does not increased and this is the main reason for unconvalesce in this disease.
Gene_expression (expression) of NGAL associated with disease
3) Confidence 0.78 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.36 Pain Relevance 0
The overexpression of NGAL has been shown to reduce the adhesion and invasion of cancer cells in vitro and in vivo [31, 32].
Gene_expression (overexpression) of NGAL associated with cancer and adhesions
4) Confidence 0.78 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.88 Pain Relevance 0.14
Tissue distribution studies have revealed that a member of this family 24p3 lipocalin (24p3) is mainly expressed in the liver during an acute phase response [21].
Gene_expression (expressed) of 24p3 in liver associated with acute-phase reaction
5) Confidence 0.75 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 1.15 Pain Relevance 0.28
Tissue distribution studies have revealed that a member of this family 24p3 lipocalin (24p3) is mainly expressed in the liver during an acute phase response [21].
Gene_expression (expressed) of 24p3 in liver associated with acute-phase reaction
6) Confidence 0.75 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 1.14 Pain Relevance 0.28
Assessment of NGAL expressions in healthy and the patients endobrinchial biopsies were performed by semiquantitative RT-PCR, real-time RT-PCR, and Immunohistochemistry analysis.
Gene_expression (expressions) of NGAL
7) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2873661 Disease Relevance 0.28 Pain Relevance 0
The unchanged expression of NGAL protein after long-term SM induction was however not parallel by increased mRNA expression.
Gene_expression (expression) of NGAL
8) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.35 Pain Relevance 0.03
To our knowledge, there have been no reports on the expression change of NGAL and its interaction with SM-induced pulmonary complications of delayed form.
Gene_expression (expression) of NGAL
9) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.34 Pain Relevance 0.09
In conclusion our study demonstrated that expression of NGAL in mRNA levels in sulfur mustard injured veterans significantly increased compared with control group.
Gene_expression (expression) of NGAL
10) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.34 Pain Relevance 0
In the latter location, its expression has been found to be coincident with parturition, a time of major tissue remodeling and inflammation [22]. 24p3 has also been detected in the conditioned media of LPS stimulated murine PU5.1.8 macrophages and therefore it has been suggested to function in defense against infectious agents [22].
Gene_expression (detected) of 24p3 in macrophages associated with inflammation
11) Confidence 0.65 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 1.26 Pain Relevance 0.26
Numerical data are expressed as mean ± SD of fold changes of NGAL gene expression in three independent experiments.
Gene_expression (expression) of NGAL
12) Confidence 0.60 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0 Pain Relevance 0
In contrast to the mRNA level, the present study showed the localization of NGAL in bronchial epithelial cells in SM-exposed and unexposed patients; no significant expression level of NGAL protein was detected in both groups.
Gene_expression (detected) of NGAL in epithelial cells
13) Confidence 0.60 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.41 Pain Relevance 0.06
Since the control samples expressed the equal level of NGAL, only two of them were used for comparison with the SM-injured patients.
Gene_expression (expressed) of NGAL
14) Confidence 0.60 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0 Pain Relevance 0
To investigate whether SM induces NGAL expression in protein level immunohistochemistry was performed.
Gene_expression (expression) of NGAL
15) Confidence 0.60 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0 Pain Relevance 0
A recent work has shown that NGAL expression was dramatically upregulated in kidney mesangial cells derived from lupus-prone mice after in vitro treatment with the murine nephritogenic anti-dsDNA monoclonal antibodies [26].
Gene_expression (expression) of NGAL in mesangial cells associated with systemic lupus erythematosus
16) Confidence 0.59 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.07 Pain Relevance 0.11
Lipocalin-2 is a small glycosylated protein produced in many tissues and organs.
Gene_expression (produced) of Lipocalin-2
17) Confidence 0.59 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.01 Pain Relevance 0.14
NGAL is constitutively expressed at low levels in the kidneys [18] but upregulated following acute renal injury and various insults such as inflammation, ischemia, and infection [19–22].
Gene_expression (expressed) of NGAL associated with inflammation, ischemia, injury and infection
18) Confidence 0.59 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.04 Pain Relevance 0.15
In light of similarities between SM-induced pulmonary complications of delayed form and a number of pulmonary disorders whose pathogenesis oxidative stress and free radicals are involved in, based on the assumption that the expression of NGAL should be altered in SM-exposed victims, the present study was designed to evaluate the expression of NGAL at levels of mRNA and protein in airway biopsy samples of SM-exposed patients in comparison with unexposed group.

2.

Gene_expression (expression) of NGAL associated with stress
19) Confidence 0.59 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.50 Pain Relevance 0.04
Semiquantitative PCR of NGAL gene was performed using recombinant Taq DNA polymerase (Cinnagene, Tehran, Iran) in a thermocycler (mastercycler eppendorf, Hamburg, Germany).
Gene_expression (using) of NGAL
20) Confidence 0.59 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0 Pain Relevance 0

General Comments

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