INT146759

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 18.44
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LCN2)
Anatomy Link Frequency
Plasma 1
liver 1
lung 1
neutrophil 1
LCN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 16 100.00 Very High Very High Very High
Inflammation 100 98.44 Very High Very High Very High
ischemia 7 97.12 Very High Very High Very High
Inflammatory response 14 96.96 Very High Very High Very High
Angina 5 94.48 High High
addiction 1 90.72 High High
Arthritis 35 86.36 High High
chemokine 28 65.40 Quite High
Inflammatory mediators 14 61.68 Quite High
cytokine 21 46.84 Quite Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 8 100.00 Very High Very High Very High
Apoptosis 86 99.84 Very High Very High Very High
Renal Disease 816 99.72 Very High Very High Very High
Injury 47 99.08 Very High Very High Very High
Disease 227 98.92 Very High Very High Very High
INFLAMMATION 128 98.44 Very High Very High Very High
Diabetes Mellitus 17 97.92 Very High Very High Very High
Systemic Lupus Erythematosus 602 97.20 Very High Very High Very High
Emphysema 21 97.20 Very High Very High Very High
Cv Unclassified Under Development 27 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it has been demonstrated that the level of HNL/NGAL was significantly increased in bronchoalveolar lavage fluid (BAL) from subjects with subclinical emphysema confirmed by computerized tomography compared with relatively heavy smoker-persons without emphysema [41].
Positive_regulation (increased) of NGAL associated with emphysema
1) Confidence 0.69 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 1.14 Pain Relevance 0.09
It seems that the upregulation of NGAL in these patients may play an advantageous role in decreasing oxidative stresses induced by ROS as a cytoprotective agent to reduce the lung injury and improve patients' symptoms, but optimal cure has not been taken place.
Positive_regulation (upregulation) of NGAL in lung associated with lung injury and stress
2) Confidence 0.61 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.31 Pain Relevance 0
While Normal control samples expressed same level of mRNA NGAL, expression level of mRNA-NGAL was upregulated about 1.4- to 9.8-folds compared to normal samples.
Positive_regulation (upregulated) of NGAL
3) Confidence 0.61 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2873661 Disease Relevance 0.25 Pain Relevance 0
As we are aware this is the first report of induction of NGAL in patients exposed to SM.
Positive_regulation (induction) of NGAL
4) Confidence 0.61 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2873661 Disease Relevance 0.23 Pain Relevance 0
They also emphasized that elevation of uNGAL might be a reflection of renal injury/inflammation, which was not specific to lupus renal disease.
Positive_regulation (elevation) of uNGAL associated with inflammation, renal disease, injury and systemic lupus erythematosus
5) Confidence 0.53 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.83 Pain Relevance 0.09
In another study, Eichler et al. [40] showed that the serum levels of HNL/NGAL in patients with cystic fibrosis were noticeably increased and strongly postulated that the determination of serum concentration of this protein may be another useful diagnostic tool for monitoring of neutrophilic inflammation in CF patients.
Spec (postulated) Positive_regulation (increased) of NGAL associated with fibrosis, inflammation and cystic fibrosis
6) Confidence 0.47 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 1.35 Pain Relevance 0.12
Increase in serum NGAL levels occurred at a much less degree and was not statistically significant.
Positive_regulation (Increase) of NGAL
7) Confidence 0.46 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.89 Pain Relevance 0.08
It was demonstrated that a significant increase in uNGAL/creatinine levels of up to 104% was detected up to 3 months before worsening of lupus nephritis as measured by all the three disease activity indices.
Positive_regulation (increase) of uNGAL associated with renal disease and disease
8) Confidence 0.46 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.83 Pain Relevance 0.07
Plasma NGAL level also increased significantly by 26% as early as 3 months before worsening of global SLE disease activity (by all three disease indices) and renal activity as measured by the BILAG renal score.
Positive_regulation (increased) of NGAL in Plasma associated with disease and systemic lupus erythematosus
9) Confidence 0.46 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.88 Pain Relevance 0.07
Although the exact pathophysilogical roles of NGAL are not currently fully understood, several possible functions have been ascribed to NGAL, such as transportation of iron and fatty acids [22, 23], induction of apoptosis [24], suppression of bacterial growth [25], and modulation of inflammatory responses [26].
Positive_regulation (induction) of NGAL associated with inflammatory response and apoptosis
10) Confidence 0.44 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0.84 Pain Relevance 0.08
As presented in Figure 1 in all SM-poisoned cases (Lanes 3–12) NGAL was upregulated (Lanes 1 and 2).
Positive_regulation (upregulated) of NGAL
11) Confidence 0.41 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2873661 Disease Relevance 0 Pain Relevance 0
NGAL is constitutively expressed at low levels in the kidneys [18] but upregulated following acute renal injury and various insults such as inflammation, ischemia, and infection [19–22].
Positive_regulation (upregulated) of NGAL associated with inflammation, ischemia, injury and infection
12) Confidence 0.38 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.11 Pain Relevance 0.16
Patients with worsening global or renal disease activity had increased levels of uNGAL and NGAL/creatinine.
Positive_regulation (increased) of uNGAL associated with renal disease
13) Confidence 0.35 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.89 Pain Relevance 0.08
Patients with worsening global or renal disease activity had increased levels of uNGAL and NGAL/creatinine.
Positive_regulation (increased) of NGAL associated with renal disease
14) Confidence 0.35 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 1.90 Pain Relevance 0.08
They concluded that higher levels of NGAL are correlated to higher cystic growth and suggested that this protein could be also involved in the process of cystogenesis [55].
Positive_regulation (levels) of NGAL
15) Confidence 0.25 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 0.65 Pain Relevance 0.07
METHODS: Serum, urinary NGAL, cystatin C, urinary kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), and liver-type fatty acid binding protein (L-FABP) were evaluated before and 2, 4, 8, 24, and 48 hours after cardiac catheterization using commercially available kits.
Positive_regulation (evaluated) of NGAL in liver
16) Confidence 0.06 Published 2009 Journal Ren Fail Section Body Doc Link 20030526 Disease Relevance 0.28 Pain Relevance 0
RESULTS: In both groups we found a significant rise in serum NGAL after 2, 4, and 8 hours, and in urinary NGAL and IL-18 after 4, 8, and 24 hours after cardiac catheterization.
Positive_regulation (urinary) of NGAL
17) Confidence 0.06 Published 2009 Journal Ren Fail Section Body Doc Link 20030526 Disease Relevance 0.24 Pain Relevance 0
RESULTS: In both groups we found a significant rise in serum NGAL after 2, 4, and 8 hours, and in urinary NGAL and IL-18 after 4, 8, and 24 hours after cardiac catheterization.
Positive_regulation (rise) of NGAL
18) Confidence 0.05 Published 2009 Journal Ren Fail Section Body Doc Link 20030526 Disease Relevance 0.25 Pain Relevance 0
Could neutrophil-gelatinase-associated lipocalin and cystatin C predict the development of contrast-induced nephropathy after percutaneous coronary interventions in patients with stable angina and normal serum creatinine values?
Positive_regulation (neutrophil-gelatinase-associated) of lipocalin in neutrophil associated with angina and renal disease
19) Confidence 0.01 Published 2007 Journal Kidney Blood Press. Res. Section Title Doc Link 17901710 Disease Relevance 0.56 Pain Relevance 0.09

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