INT146784

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Context Info
Confidence 0.74
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 4.41
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MYOD1) nucleus (MYOD1) enzyme binding (MYOD1)
DNA binding (MYOD1) transcription factor binding (MYOD1) cytoplasm (MYOD1)
Anatomy Link Frequency
myoblast 1
myocytes 1
cardiomyocytes 1
muscle 1
skeletal muscle 1
MYOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 10 87.52 High High
Pain 12 74.00 Quite High
Kinase C 5 65.72 Quite High
opioid receptor 3 64.88 Quite High
agonist 3 63.76 Quite High
Dynorphin 7 62.44 Quite High
imagery 52 5.00 Very Low Very Low Very Low
Inflammation 37 5.00 Very Low Very Low Very Low
complementary and alternative medicine 27 5.00 Very Low Very Low Very Low
Acupuncture 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 21 99.84 Very High Very High Very High
Muscular Dystrophy 72 99.04 Very High Very High Very High
Rhabdomyosarcoma 17 98.56 Very High Very High Very High
Rhinitis 1 95.16 Very High Very High Very High
Osteogenic Sarcomas 4 93.12 High High
Reprotox - General 1 3 92.64 High High
Malignant Neoplastic Disease 3 91.52 High High
Frailty 84 88.16 High High
Bone Cancer 2 87.76 High High
Chondrosarcoma 1 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Desmin, actin, Myf4, and MyoD1 were positive in tumor cells, and a diagnosis of rhabdomyosarcoma was eventually made.
Gene_expression (positive) of MyoD1 associated with cancer and rhabdomyosarcoma
1) Confidence 0.74 Published 2007 Journal Pathol. Res. Pract. Section Abstract Doc Link 17905523 Disease Relevance 1.49 Pain Relevance 0.07
RT-PCR analysis revealed the expression of M-cadherin, Myf-5, Myogenin, Pax7, MyoD and MRF4 in normal and DMD CD133+CXCR4+CD34- cells after 7 days of co-culture.
Gene_expression (expression) of MyoD associated with muscular dystrophy
2) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.25 Pain Relevance 0
These concerns and procedures – different as they may appear at first glance – point to the same important problem, namely the unclear or questionable relationships between the body, the self-determination of one and the same person, and its public articulation: What am I allowed to do with my own body, and to what extent can I permit others to do 'whatever they like' with their bodies?
Gene_expression (body) of self-determination in body
3) Confidence 0.47 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2180175 Disease Relevance 0.21 Pain Relevance 0.12
Immunohistochemical stains revealed that the tumor cells were positive for vimentin, desmin and myod1.
Gene_expression (positive) of myod1 associated with cancer
4) Confidence 0.41 Published 2003 Journal World J Surg Oncol Section Body Doc Link PMC222905 Disease Relevance 1.41 Pain Relevance 0.03
In general, studies that have compared the expression of MRFs such as myogenic determination factor (myoD), myogenic regulatory factor 5, and myogenin in rats have found that expression of these factors is decreased in older compared to younger skeletal muscle [51].
Gene_expression (expression) of myoD in skeletal muscle
5) Confidence 0.29 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.06 Pain Relevance 0
Another factor in the behavior of muscle satellite cells is myostatin, which is thought to suppress differentiation and proliferation of myocytes by suppressing the expression of MRFs such as myoD and myogenin [53].
Gene_expression (expression) of myoD in myocytes
6) Confidence 0.29 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.15 Pain Relevance 0
At day 7 and day 14 total RNA was extracted for RT-PCR in order to investigate the expression of MyoD and myogenin respectively.
Spec (investigate) Gene_expression (expression) of MyoD
7) Confidence 0.28 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1810523 Disease Relevance 0 Pain Relevance 0.07
Nevertheless, there was no apparent sex difference in these responses, which makes it unlikely that the feeding-induced changes in myostatin and myoD expression contributed to the blunted increase of MPS to feeding in women.
Gene_expression (expression) of myoD
8) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.11 Pain Relevance 0
An intriguing new finding was the marked (and so far as we can tell previously unreported) changes in the expression of myostatin and myoD with feeding, which are consistent with an acute nutritional control at the level of the nucleus of processes regulating muscle mass [55].
Gene_expression (expression) of myoD in nucleus
9) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.06 Pain Relevance 0
The following primers were used for myostatin and myoD (all 5?
Gene_expression (used) of myoD
10) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0 Pain Relevance 0
In addition, amniotic membrane-isolated cells underwent in vitro osteogenic (von Kossa stain), adipogenic (Oil Red-O stain), chondrogenic (collagen type II immunohistochemichal detection) and myogenic (RT-PCR MyoD and Myogenin expression as well as desmin immunohistochemical detection) differentiation.
Gene_expression (expression) of MyoD
11) Confidence 0.22 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1810523 Disease Relevance 0 Pain Relevance 0
Furthermore, the expression in muscle of mRNA for myostatin and myoD, cell regulatory proteins affecting muscle size [26]–[29], was not different between the sexes, which makes it unlikely that they are involved in regulating the basal rate of MPS, although, we cannot from our data rule out differences in the muscle myostatin and myoD protein concentration (and thus in cell function).
Gene_expression (expression) of myoD in muscle
12) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.17 Pain Relevance 0
Noteworthy in this study is the fact that the expression of MyoD, a gene involved in skeletal myogenesis, was not affected in either EBs or ES-derived cardiomyocytes.
Gene_expression (expression) of MyoD in cardiomyocytes
13) Confidence 0.09 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193541 Disease Relevance 0 Pain Relevance 0.24
Here we describe the generation of immortalized myoblast cell lines derived from healthy (DMPK CTG5) and DM1 patient (DMPK CTG1000) fibroblasts by constitutive overexpression of human telomerase reverse transcriptase (hTERT) and inducible overexpression of the Myoblast determination factor (MYOD).
Gene_expression (overexpression) of Myoblast determination factor in myoblast
14) Confidence 0.07 Published 2010 Journal Current Chemical Genomics Section Abstract Doc Link PMC2874217 Disease Relevance 0.49 Pain Relevance 0

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