INT146785

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.16
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
colon 2
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 8 99.80 Very High Very High Very High
rheumatoid arthritis 114 93.52 High High
addiction 4 86.08 High High
cINOD 2 83.84 Quite High
Nerve growth factor 1 81.92 Quite High
Osteoarthritis 6 76.64 Quite High
Inflammatory response 17 73.92 Quite High
Inflammation 80 64.24 Quite High
cytokine 4 51.60 Quite High
Arthritis 16 50.00 Quite Low
Disease Link Frequency Relevance Heat
Overdose 2 99.98 Very High Very High Very High
Parkinson's Disease 118 99.88 Very High Very High Very High
Death 68 99.24 Very High Very High Very High
Cv Unclassified Under Development 68 99.04 Very High Very High Very High
Apoptosis 102 98.58 Very High Very High Very High
Colon Cancer 11 98.36 Very High Very High Very High
Necrosis 10 97.60 Very High Very High Very High
Rheumatoid Arthritis 116 93.52 High High
Hepatotoxicity 2 91.36 High High
Starvation 2 91.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APAP overdose induced Bax translocation from the cytosol to the mitochondria as early as 1 h after APAP injection.
Positive_regulation (induced) of Localization (translocation) of Bax associated with paracetamol and overdose
1) Confidence 0.69 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17906064 Disease Relevance 0.57 Pain Relevance 0.60
DIM-C-pPhOCH(3) induced caspase-dependent apoptosis in RKO colon cancer cells through decreased mitochondrial membrane potential which is accompanied by increased mitochondrial bax/bcl-2 ratios and release of cytochrome c into the cytosol.
Positive_regulation (increased) of Localization (release) of bax in colon associated with colon cancer and apoptosis
2) Confidence 0.49 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 17957723 Disease Relevance 0.70 Pain Relevance 0.12
In this model, the expression of BH3-only proteins competed with BCLXL:BAX dimers and facilitated the release of BAX allowing to become active.
Positive_regulation (facilitated) of Localization (release) of BAX
3) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.75 Pain Relevance 0.08
Furthermore, VEGF165 completely blocked SNP-induced Bcl-2 downregulation and SNP-induced Bax translocation from the cytosol to mitochondria.
Positive_regulation (induced) of Localization (translocation) of Bax
4) Confidence 0.25 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.91 Pain Relevance 0.26
Furthermore, the downregulation of NP-1 transcripts by short interfering RNA caused spontaneous synoviocyte apoptosis, which was associated with both a decrease in Bcl-2 expression and an increase in Bax translocation to mitochondria.
Positive_regulation (increase) of Localization (translocation) of Bax associated with apoptosis
5) Confidence 0.25 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.85 Pain Relevance 0.33
Using 27-mer peptides derived from the C-terminal sequence of PB1-F2 and chimeric viruses engineered on a common background, we demonstrated that induction of cell death through PB1-F2 is dependent upon BAK/BAX mediated cytochrome c release from mitochondria.
Positive_regulation (mediated) of Localization (release) of BAX associated with death
6) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2908617 Disease Relevance 1.04 Pain Relevance 0.07
However, these studies relied on cytochrome c release as a measure of MPTP opening, but it is known that this can occur independently of the MPTP as a result of Bax translocation to mitochondria during ischaemia [72].
Positive_regulation (result) of Localization (translocation) of Bax associated with parkinson's disease and cv unclassified under development
7) Confidence 0.12 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 1.33 Pain Relevance 0

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