INT146793

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 32.93
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
fibroblasts 3
brain 1
apoptotic cells 1
neuronal 1
fat 1
Tp53 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 24 96.56 Very High Very High Very High
cytokine 24 93.00 High High
Inflammation 163 92.72 High High
rheumatoid arthritis 84 91.44 High High
Arthritis 295 88.84 High High
fibrosis 75 82.56 Quite High
Crohn's disease 5 74.72 Quite High
Chronic pancreatitis 5 72.96 Quite High
GABAergic 3 70.24 Quite High
Bile 15 64.40 Quite High
Disease Link Frequency Relevance Heat
Dna Damage 3 99.96 Very High Very High Very High
Apoptosis 673 99.92 Very High Very High Very High
Hypoxia 26 99.84 Very High Very High Very High
Cancer 796 99.82 Very High Very High Very High
Prostate Cancer 112 99.80 Very High Very High Very High
Autism 247 99.48 Very High Very High Very High
Myocardial Infarction 83 99.46 Very High Very High Very High
Reprotox - General 1 1 99.36 Very High Very High Very High
Cerebral Hypoxia 3 98.98 Very High Very High Very High
Glioblastoma 51 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DNA damage activates

p53, thereby inducing cell growth arrest to allow time for DNA repair.

Positive_regulation (activates) of p53
1) Confidence 0.70 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.19 Pain Relevance 0.05
The number of apoptotic cells in WB-2054-M5 cells after transfection of wild-type p53 increased and the apoptotic index markedly increased in the Ad5CMV-p53 group.
Positive_regulation (increased) of p53 in apoptotic cells associated with apoptosis
2) Confidence 0.68 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.53 Pain Relevance 0
Inactivation of

the p53 gene renders cells less susceptible to undergo apoptosis [12].

Positive_regulation (Inactivation) of p53 associated with apoptosis
3) Confidence 0.50 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.11 Pain Relevance 0.03
In the cell cycle assay, the G1/S ratio was markedly increased in the Ad5CMV-p53 group.
Positive_regulation (increased) of p53
4) Confidence 0.49 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.03 Pain Relevance 0
These results support a role for p53 gene therapy as an adjunct to current therapies available for cancers with mutations in this tumor suppressor gene.
Positive_regulation (role) of p53 associated with cancer
5) Confidence 0.49 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.52 Pain Relevance 0
In vivo Recombinant Adenovirus-mediated p53 Gene Therapy in a Syngeneic Rat Model for Colorectal Cancer

The p53 gene has a significant role in controlling genomic stability of cancer.

Positive_regulation (mediated) of p53 associated with colorectal cancer, genomic instability and cancer
6) Confidence 0.49 Published 2004 Journal Journal of Korean Medical Science Section Title Doc Link PMC2816308 Disease Relevance 1.09 Pain Relevance 0
The positive results from the in vitro experiments encouraged the recombinant adenovirus-mediated p53 gene therapy in the syngeneic rat model for colorectal cancer.
Positive_regulation (mediated) of p53 associated with colorectal cancer
7) Confidence 0.49 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.76 Pain Relevance 0
Similarly, exposure of human fibroblasts

to nitric oxide generated from a nitric oxide donor or from overexpression of inducible nitric oxide synthase may result in accumulation of wild-type p53 [31].

Positive_regulation (accumulation) of p53 in fibroblasts
8) Confidence 0.47 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.71 Pain Relevance 0.57
Activation of p53 leads to induction of cell growth

arrest, allowing time for DNA repair.

Positive_regulation (Activation) of p53
9) Confidence 0.47 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 2.00 Pain Relevance 0.46
Activation of p53 leads to induction of cell

growth arrest, allowing time for DNA repair.

Positive_regulation (Activation) of p53
10) Confidence 0.47 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 1.53 Pain Relevance 0.36
According to our results, however apoptosis was increased in the GK + MI rat heart in spite of the increased Sirt1-p53 deacetylation, although modestly with only 0.20% TUNEL-positive cells in the border zone of GK + MI rats.
Positive_regulation (increased) of p53 in heart associated with apoptosis and myocardial infarction
11) Confidence 0.42 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.29 Pain Relevance 0.03
Although there were positive reactions for cleaved caspase-3 or p53 in the septal nucleus after axotomy, they did not co-localize with ChAT, p75 or the general neuronal marker NeuN (Figure 4A, B, C).
Positive_regulation (cleaved) of p53 in neuronal
12) Confidence 0.18 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.47 Pain Relevance 0.09
There are several studies that demonstrate evidence of cerebral hypoxia, as measured by a reduction in brain Bcl-2 and an increase in brain p53, among some autistic individuals [68-71].
Positive_regulation (increase) of p53 in brain associated with autism and cerebral hypoxia
13) Confidence 0.12 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC2244616 Disease Relevance 1.68 Pain Relevance 0
Cellular stress (such as deoxyribonucleic acid damage, hypoxia, and oxidized lipoprotein) activates p53.
Positive_regulation (activates) of p53 associated with stress and hypoxia
14) Confidence 0.12 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.49 Pain Relevance 0
The increase in p53 protein normally activates other genes or factors to cause cell cycle arrest, DNA repair or to induce apoptosis (34).
Positive_regulation (increase) of p53 associated with apoptosis
15) Confidence 0.11 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538507 Disease Relevance 0.58 Pain Relevance 0
In p53-deficient mice, the induced WOX1 nuclear accumulation occurs
               similarly to that in normal controls, indicating that WOX1 activation is independent
               of p53. 
Positive_regulation (activation) of p53
16) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.69 Pain Relevance 0.05
B appeared in the network simply because it is a highly connected node in the database, the in PathwayAssist equally highly connected node "protein tumor protein p53" was manually included into the network and tested for its connectivity with the CRPS concepts.
Positive_regulation (tested) of p53 in node associated with complex regional pain syndromes and cancer
17) Confidence 0.09 Published 2007 Journal J Biomed Discov Collab Section Body Doc Link PMC1871567 Disease Relevance 0.37 Pain Relevance 0
Elevated p53 is induced by hypoxia [72] and a decrease in Bcl-2 is associated with increased apoptosis provoked by hypoxia [73].
Positive_regulation (Elevated) of p53 associated with hypoxia and apoptosis
18) Confidence 0.08 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC2244616 Disease Relevance 1.70 Pain Relevance 0
Elevated p53 is induced by hypoxia [72] and a decrease in Bcl-2 is associated with increased apoptosis provoked by hypoxia [73].
Positive_regulation (induced) of p53 associated with hypoxia and apoptosis
19) Confidence 0.08 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC2244616 Disease Relevance 1.71 Pain Relevance 0
In addition, PFD downregulated mRNA expression of CsA-induced p53 and Fas-ligand and increased that of Bcl-xL, which had previously been reduced by CsA.
Positive_regulation (induced) of p53
20) Confidence 0.08 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.95 Pain Relevance 0.10

General Comments

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