INT146794

Context Info Confidence 0.50 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.21 Pain Relevance 0

hydrolase activity, acting on glycosyl bonds (Gla) extracellular region (Gla) Golgi apparatus (Gla) lysosome (Gla) cytoplasm (Gla)

Anatomy Link Frequency AGS 1 Gla (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 4 26.24 Pain 1 25.00 Inflammation 11 19.84 Inflammatory response 2 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Alagille Syndrome 22 100.00 Stress 8 98.68 Stomach Cancer 22 92.28 Anxiety Disorder 1 77.20 Cancer 32 50.00 Necrosis 3 50.00 INFLAMMATION 14 19.84 Infection 8 5.00 Targeted Disruption 6 5.00 Polyps 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Results indicate that although reduced stress reactivity promotes exploration, this does not translate into an up-regulation of GLA, suggesting that the relationship between GLA and exploration is not mediated by stress reactivity.

Positive_regulation (up-regulation) of GLA associated with stress

1) Confidence 0.50 Published 2007 Journal Behav. Neurosci. Section Abstract Doc Link 17907827 Disease Relevance 0.66 Pain Relevance 0

stimulation in both AGS and Kato-III cells (Figure 5C).

Positive_regulation (stimulation) of AGS in AGS associated with alagille syndrome

2) Confidence 0.04 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.55 Pain Relevance 0

General Comments

This test has worked.