INT146801

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.40
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Ccnd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 1 99.20 Very High Very High Very High
cINOD 1 97.92 Very High Very High Very High
COX-2 inhibitor 1 86.16 High High
cva 1 39.16 Quite Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 2 98.94 Very High Very High Very High
Apoptosis 9 98.68 Very High Very High Very High
INFLAMMATION 1 97.20 Very High Very High Very High
Cancer 78 95.56 Very High Very High Very High
Toxicity 12 91.32 High High
Parathyroid Cancer 40 84.56 Quite High
Thyroid Neoplasm 19 84.00 Quite High
Glioma 24 82.68 Quite High
Colon Cancer 1 75.64 Quite High
Metastasis 3 69.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of Ccnd1, Ccnd3, and Jun mRNA (all transcriptional targets of Wnt signaling) are suggestive of increased risk to human cancer (Behrens 2000; Ishigaki et al. 2002).
Regulation (regulation) of Ccnd1 associated with cancer
1) Confidence 0.34 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.44 Pain Relevance 0
Exisulind in combination with celecoxib modulates epidermal growth factor receptor, cyclooxygenase-2, and cyclin D1 against prostate carcinogenesis: in vivo evidence.
Regulation (modulates) of cyclin D1 associated with cox2
2) Confidence 0.18 Published 2007 Journal Clin. Cancer Res. Section Title Doc Link 17908994 Disease Relevance 0.19 Pain Relevance 0.19
For example, there is the down-regulation of cyclin D1, cyclin-dependent kinase 4, c-myc and Bcl-2 [19, 24].
Regulation (regulation) of cyclin D1
3) Confidence 0.16 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0.09 Pain Relevance 0
Breast cancer cases known to express Cyclin D1 served as positive control for Cyclin D1.
Regulation (control) of Cyclin D1 associated with breast cancer
4) Confidence 0.07 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2627811 Disease Relevance 0.77 Pain Relevance 0
Increased p53 expression together with these changes in pRb and cyclin D1 can significantly increase cell apoptosis [37-39].
Regulation (changes) of cyclin D1 associated with apoptosis
5) Confidence 0.05 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.92 Pain Relevance 0

General Comments

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