INT146802

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Context Info
Confidence 0.38
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.37
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
mammary gland 1
esophagus 1
Ccnd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 1 99.20 Very High Very High Very High
cINOD 8 97.92 Very High Very High Very High
COX-2 inhibitor 8 86.16 High High
Inflammation 9 70.56 Quite High
Bile 2 52.92 Quite High
aspirin 2 36.76 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 97.20 Very High Very High Very High
Cancer 72 95.56 Very High Very High Very High
Targeted Disruption 3 91.60 High High
Toxicity 12 91.32 High High
Adenocarcinoma 22 87.76 High High
Thyroid Neoplasm 18 84.00 Quite High
Hyperplasia 6 61.20 Quite High
Hypertrophy 8 50.48 Quite High
Duodenogastric Reflux 1 45.76 Quite Low
Apoptosis 5 40.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study showed that cyclin D1 and PCNA expression were increased in the lower esophagus of rats exposed to gastroduodenal reflux contents.
Positive_regulation (increased) of cyclin D1 in esophagus
1) Confidence 0.38 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628171 Disease Relevance 0.45 Pain Relevance 0.34
Up-regulation of Ccnd1, Ccnd3, and Jun mRNA (all transcriptional targets of Wnt signaling) are suggestive of increased risk to human cancer (Behrens 2000; Ishigaki et al. 2002).
Positive_regulation (Up-regulation) of Ccnd1 associated with cancer
2) Confidence 0.35 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.44 Pain Relevance 0
Exisulind in combination with celecoxib modulates epidermal growth factor receptor, cyclooxygenase-2, and cyclin D1 against prostate carcinogenesis: in vivo evidence.
Positive_regulation (modulates) of cyclin D1 associated with cox2
3) Confidence 0.33 Published 2007 Journal Clin. Cancer Res. Section Title Doc Link 17908994 Disease Relevance 0.19 Pain Relevance 0.19
D'Cruz and coworkers [8] previously showed that cyclin D1 mRNA levels are increased in the mammary gland of parous rats as compared with age-matched virgin animals.
Positive_regulation (increased) of cyclin D1 mRNA in mammary gland
4) Confidence 0.22 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.29 Pain Relevance 0

General Comments

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